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Prof Peter Crowley

B.Sc.,Ph.D.

Contact Details

Professor
Orbsen Buildng, Laboratory 211
School of Biological and Chemical Sciences
University of Galway
T: +353 91 49 2480
 
researcher
 

Biography

After graduating with first class honours in chemistry Peter joined the laboratory of Prof. G. W. Canters at Leiden University, The Netherlands. Working with his advisor Prof. M. Ubbink, he used NMR spectroscopy to study transient protein interactions involved in electron transport. This research was summarized in Accounts of Chemical Research (2003).

From the Netherlands Peter headed south for sunnier climes. With a Marie Curie Postdoctoral fellowship he joined the lab of Prof. M. A. Carrondo at Universidade Nova de Lisboa, Portugal. During this time he further developed his interest in molecular recognition. In particular, he demonstrated the importance of cation-pi interactions in protein-protein interfaces.

In 2006, Peter returned to Ireland, working as a lecturer in Biochemistry at University College Dublin, and since 2008 as a lecturer in Chemistry at Galway. He was promoted in 2014 to Senior Lecturer and in 2017 to Personal Professor. Current interests include protein assembly using the tools of supramolecular chemistry. For more information see publications. His research on protein - cailxarene recognition and assembly was summarized in Accounts of Chemical Research (2022). 

Research Interests

- Molecular Recognition
- Protein Interactions
- Self Assembly
- Supramolecular Chemistry
- Macrocycles
- Structural Biology
- NMR spectroscopy / X-ray crystallography
- In-cell NMR spectroscopy
- PEGylation

A recent essay on host - guest chemistry:

Review paper on ~10 years of protein - calixarene research at Galway.


Video by Ciara Kyne and CELT on protein interactions in cell extracts
https://www.youtube.com/watch?v=_549N4wHCjk

Highlight of our Nature Chemistry 2012 paper
https://www.youtube.com/watch?v=pOTWEPF925c

Video by James Ward and William Smith for "distil life' exhibition in 2011
https://vimeo.com/32684138


Research Projects

  Project Start Date End Date
Protein Crystalline Frameworks via Supramolecular Chemistry 01-OCT-19 30-SEP-21
SSPC Centre for Pharmaceutical Research - Peter Crowley - Manufacturing - Phase 2 01-JUN-19 31-MAY-25
RSC OUTREACH - SCHOOL OF CHEMISTRY 01-NOV-16 31-OCT-19
IRC Year Post Doctoral Fellowship 2016 Veera Venkata Sreenivasu Mummidivarapu - Synthesis and Structural Biology of Novel Ligands for Noncovalent PEGylation 01-OCT-16 30-SEP-17
SUPRAMOLECULAR APPROACHES TO PROTEIN SURFACE RECOGNITION AND SELF ASSEMBLEY 01-SEP-14 31-MAY-23
SUPRAMOLECULAR APPROACHES TO PROTEIN SURFACE RECOGNITION AND ASSEMBLY SUPRASURF PETER CROWLEY 01-JUL-14 27-FEB-18
GALWAY NATURAL HEALTH SALES CO IV PETER CROWLEY 29-NOV-12 29-NOV-14
BIOELECTRONICS PETER CROWLEY 01-NOV-12 30-SEP-14
PROTEIN SURFING, STRUCTURAL CHARACTERISATION OF PROTEIN SURFACE LIGANDS, PETER CROWLEY 23-AUG-12 15-JUN-13
NMR FACILITY SCHOOL OF CHEMISTRY PETER CROWLEY 13-JUL-12 13-JUL-17
SFI WALTON PROTEIN CHEMISTRY IN LIVING CELLS 11 W.1 B2067 10-APR-12 31-AUG-13
STRUCTURAL STUDIES TOWARDS THE DISCOVERY OF LECTIN INHIBITORS MILL FUND PETER CROWLEY 01-FEB-12 30-MAY-15
GENERAL ACCOUNT FOR PETER CROWLEY 23-NOV-11 31-DEC-20
E.I. ENT IRL IV 2010 3338 COLLABORATION WITH IRISH ORGANIC WEEDKILLER LTD PETER CROWLEY 01-MAR-11 31-AUG-11
Protein Probes: From Self Assembly to In Vivo Trafficking 01-SEP-10 31-AUG-16
MILLENNIUM FUND MF09 P02 PETER CROWLEY 01-JAN-10 31-DEC-10
EXPLORING THE PROTEIN SURFACE MF08P39 P CROWLEY 10-DEC-08 09-DEC-09
JOURNEY CENTRE CELL 07/RFP/VICF236 P CROWLEY 01-SEP-07 31-AUG-10

Peer Reviewed Journals

  Year Publication
(2023) 'Origins of the Host¿Guest Terminology'
PB Crowley (2023) 'Origins of the Host¿Guest Terminology'. Crystal Growth & Design, [Details]
(2023) 'Solid-state NMR¿a complementary technique for protein framework characterization'
L Cerofolini, KO Ramberg, LC Padilla, P Antonik, E Ravera, C Luchinat, M Fragai, PB Crowley (2023) 'Solid-state NMR¿a complementary technique for protein framework characterization'. Chemical Communications (Cambridge, England), [Details]
(2022) 'Protein¿calixarene complexation: from recognition to assembly'
PB Crowley (2022) 'Protein¿calixarene complexation: from recognition to assembly'. Accounts Of Chemical Research, [Details]
(2021) 'Facile fabrication of protein¿macrocycle frameworks'
KO Ramberg, S Engilberge, T Skorek, PB Crowley (2021) 'Facile fabrication of protein¿macrocycle frameworks'. Journal Of The American Chemical Society, [Details]
(2020) 'Metal-mediated protein¿cucurbituril crystalline architectures'
F Guagnini, S Engilberge, RJ Flood, KO Ramberg, PB Crowley (2020) 'Metal-mediated protein¿cucurbituril crystalline architectures'. Crystal Growth & Design, [Details]
(2020) 'Engineered assembly of a protein¿cucurbituril biohybrid'
F Guagnini, S Engilberge, KO Ramberg, J Pérez, PB Crowley (2020) 'Engineered assembly of a protein¿cucurbituril biohybrid'. Chemical Communications (Cambridge, England), [Details]
(2020) 'Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix [4] arene'
JM Alex, G Brancatelli, S Volpi, C Bonaccorso, A Casnati, S Geremia, PB Crowley (2020) 'Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix [4] arene'. Organic & Biomolecular Chemistry, 18 (2) [Details]
(2024) 'Multivalent Calixarene Complexation of a Designed Pentameric Lectin'
Flood RJ, Cerofolini L, Fragai M, Crowley PB. (2024) 'Multivalent Calixarene Complexation of a Designed Pentameric Lectin'. Biomacromolecules, [Details]
(2024) 'Supramolecular Synthons in Protein-Ligand Frameworks'
Flood RJ, Mockler NM, Thureau A, Malinska M, Crowley PB (2024) 'Supramolecular Synthons in Protein-Ligand Frameworks'. Crystal Growth & Design, [Details]
(2021) 'The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair'
Luessing J, Sakhteh M, Sarai N, Frizzell L, Tsanov N, Ramberg KO, Maretto S, Crowley PB, Lowndes NF. (2021) 'The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair'. Cell Reports, [DOI] [Details]
(2019) 'Tuning Protein Frameworks via Auxiliary Supramolecular Interactions'
Engilberge S, Rennie ML, Dumont E, Crowley PB. (2019) 'Tuning Protein Frameworks via Auxiliary Supramolecular Interactions'. ACS Nano, [ARAN Link] [Details]
(2019) 'Supramolecular stacking in a high: Z ′ calix[8]arene-porphyrin assembly'
Jimi M. Alex, Patrick McArdle and Peter B. Crowley (2019) 'Supramolecular stacking in a high: Z ′ calix[8]arene-porphyrin assembly'. Crystengcomm, [ARAN Link] [Details]
(2019) 'A Thermodynamic Model of Auto-regulated Protein Assembly by a Supramolecular Scaffold'
Rennie, ML;Crowley, PB (2019) 'A Thermodynamic Model of Auto-regulated Protein Assembly by a Supramolecular Scaffold'. Chemphyschem, 20 :1011-1017 [DOI] [ARAN Link] [Details]
(2019) 'Calixarene-mediated assembly of a small antifungal protein'
Alex, JM,Rennie, ML,Engilberge, S,Lehoczki, G,Dorottya, H,Fizil, A,Batta, G,Crowley, PB (2019) 'Calixarene-mediated assembly of a small antifungal protein'. Iucrj, 6 :238-247 [DOI] [ARAN Link] [Details]
(2018) 'Phosphonated Calixarene as a Molecular Glue for Protein Crystallization'
Alex, JM,Rennie, ML,Volpi, S,Sansone, F,Casnati, A,Crowley, PB (2018) 'Phosphonated Calixarene as a Molecular Glue for Protein Crystallization'. Crystal Growth & Design, 18 :2467-2473 [DOI] [Details]
(2018) 'Cucurbit[7]uril-Dimethyllysine Recognition in a Model Protein'
Guagnini, F,Antonik, PM,Rennie, ML,O'Byrne, P,Khan, AR,Pinalli, R,Dalcanale, E,Crowley, PB (2018) 'Cucurbit[7]uril-Dimethyllysine Recognition in a Model Protein'. Angewandte Chemie-International Edition, 57 :7126-7130 [DOI] [Details]
(2018) 'Auto-regulated Protein Assembly on a Supramolecular Scaffold'
Rennie, ML,Fox, GC,Perez, J,Crowley, PB (2018) 'Auto-regulated Protein Assembly on a Supramolecular Scaffold'. Angewandte Chemie-International Edition, 57 :13764-13769 [DOI] [Details]
(2018) 'Protein Recognition by Functionalized Sulfonatocalix[4]arenes'
Doolan, AM,Rennie, ML,Crowley, PB (2018) 'Protein Recognition by Functionalized Sulfonatocalix[4]arenes'. Chemistry-A European Journal, 24 :984-991 [DOI] [Details]
(2017) 'Protein Dimerization on a Phosphonated Calix[6]arene Disc'
Rennie, ML,Doolan, AM,Raston, CL,Crowley, PB (2017) 'Protein Dimerization on a Phosphonated Calix[6]arene Disc'. Angewandte Chemie-International Edition, 56 :5517-5521 [DOI] [Details]
(2017) 'Protein charge determination and implications for interactions in cell extracts'
Kyne, C,Jordon, K,Filoti, DI,Laue, TM,Crowley, PB (2017) 'Protein charge determination and implications for interactions in cell extracts'. Protein Science, 26 :258-267 [DOI] [Details]
(2016) 'Grasping the nature of the cell interior: from Physiological Chemistry to Chemical Biology'
Kyne C, Crowley PB. (2016) 'Grasping the nature of the cell interior: from Physiological Chemistry to Chemical Biology'. Febs J, [DOI] [Details]
(2016) 'Protein Camouflage: Supramolecular Anion Recognition by Ubiquitin'
Mallon, M,Dutt, S,Schrader, T,Crowley, PB (2016) 'Protein Camouflage: Supramolecular Anion Recognition by Ubiquitin'. Chembiochem, 17 :774-783 [DOI] [Details]
(2016) 'Noncovalent PEGylation via Lectin-Glycopolymer Interactions'
Antonik, PM,Eissa, AM,Round, AR,Cameron, NR,Crowley, PB (2016) 'Noncovalent PEGylation via Lectin-Glycopolymer Interactions'. Biomacromolecules, 17 :2719-2725 [DOI] [Details]
(2016) 'Anomer-Specific Recognition and Dynamics in a Fucose-Binding Lectin'
Antonik, PM,Volkov, AN,Broder, UN,Lo Re, D,van Nuland, NAJ,Crowley, PB (2016) 'Anomer-Specific Recognition and Dynamics in a Fucose-Binding Lectin'. Biochemistry, 55 :1195-1203 [DOI] [Details]
(2015) 'Structural study of a small molecule receptor bound to dimethyllysine in lysozyme'
McGovern, RE,Snarr, BD,Lyons, JA,McFarlane, J,Whiting, AL,Paci, I,Hof, F,Crowley, PB (2015) 'Structural study of a small molecule receptor bound to dimethyllysine in lysozyme'. Chemical Science, 6 :442-449 [DOI] [Details]
(2015) 'Specific ion effects on macromolecular interactions in Escherichia coli extracts'
Kyne, C,Ruhle, B,Gautier, VW,Crowley, PB (2015) 'Specific ion effects on macromolecular interactions in Escherichia coli extracts'. Protein Science, 24 :310-318 [DOI] [Details]
(2015) 'Microscale Crystals of Cytochromec and Calixarene on Electrodes: Interprotein Electron Transfer between Defined Sites'
McGovern, RE,Feifel, SC,Lisdat, F,Crowley, PB (2015) 'Microscale Crystals of Cytochromec and Calixarene on Electrodes: Interprotein Electron Transfer between Defined Sites'. Angewandte Chemie-International Edition, 54 :6356-6359 [DOI] [Details]
(2015) 'Structure of a PEGylated protein reveals a highly porous double-helical assembly'
Cattani, G,Vogeley, L,Crowley, PB (2015) 'Structure of a PEGylated protein reveals a highly porous double-helical assembly'. Nature Chemistry, 7 :823-828 [DOI] [Details]
(2014) 'Study of Cytochrome c-DNA Interaction - Evaluation of Binding Sites on the Redox Protein'
Wettstein, C,Kyne, C,Doolan, AM,Mohwald, H,Crowley, PB,Lisdat, F (2014) 'Study of Cytochrome c-DNA Interaction - Evaluation of Binding Sites on the Redox Protein'. Nanoscale, 6 :13779-13786 [DOI] [Details]
(2014) 'Protein assembly mediated by sulfonatocalix[4]arene'
McGovern, RE,McCarthy, AA,Crowley, PB (2014) 'Protein assembly mediated by sulfonatocalix[4]arene'. Chemical Communications, 50 :10412-10415 [DOI] [Details]
(2014) 'Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)'
Theillet, FX,Binolfi, A,Frembgen-Kesner, T,Hingorani, K,Sarkar, M,Kyne, C,Li, CG,Crowley, PB,Gierasch, L,Pielak, GJ,Elcock, AH,Gershenson, A,Selenko, P (2014) 'Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)'. Chemical Reviews, 114 :6661-6714 [DOI] [Details]
(2012) 'Simple and inexpensive incorporation of (19)F-Tryptophan for protein NMR spectroscopy'
Crowley PB, Kyne C, Monteith WB. (2012) 'Simple and inexpensive incorporation of (19)F-Tryptophan for protein NMR spectroscopy'. Chemical Communications (Cambridge, England), [Details]
(2012) 'Simple and inexpensive incorporation of F-19-Tryptophan for protein NMR spectroscopy'
Crowley, PB;Kyne, C;Monteith, WB (2012) 'Simple and inexpensive incorporation of F-19-Tryptophan for protein NMR spectroscopy'. Chemical Communications, 48 :10681-10683 [DOI] [Details]
(2012) 'Protein camouflage in cytochrome c-calixarene complexes'
McGovern, RE;Fernandes, H;Khan, AR;Power, NP;Crowley, PB (2012) 'Protein camouflage in cytochrome c-calixarene complexes'. Nature Chemistry, 4 :527-533 [DOI] [Details]
(2012) 'Protein camouflage in cytochrome c-calixarene complexes'
McGovern, RE,Fernandes, H,Khan, AR,Power, NP,Crowley, PB (2012) 'Protein camouflage in cytochrome c-calixarene complexes'. Nature Chemistry, 4 :527-533 [DOI] [Details]
(2011) 'Protein Interactions in the Escherichia coli Cytosol: An Impediment to In-Cell NMR Spectroscopy'
Crowley, PB,Chow, E,Papkovskaia, T (2011) 'Protein Interactions in the Escherichia coli Cytosol: An Impediment to In-Cell NMR Spectroscopy'. Chembiochem, 12 :1043-1048 [DOI] [Details]
(2011) 'Protein Interactions in the Escherichia coli Cytosol: An Impediment to In-Cell NMR Spectroscopy'
Crowley,P.B.,Chow, E.,Papkovskaia, T. (2011) 'Protein Interactions in the Escherichia coli Cytosol: An Impediment to In-Cell NMR Spectroscopy'. ChemBioChem, 12 (7):1043-1048 [DOI] [Details]
(2010) 'Titration_DB: Storage and analysis of NMR-monitored protein pH titration curves'
Farrell, D;Miranda, ES;Webb, H;Georgi, N;Crowley, PB;McIntosh, LP;Nielsen, JE (2010) 'Titration_DB: Storage and analysis of NMR-monitored protein pH titration curves'. Proteins-Structure Function And Bioinformatics, 78 :843-857 [DOI] [Details]
(2010) 'Titration_DB: Storage analysis of NMR-monitored protein pH titration curves'
Farrell,D., Sá-Mira,E., Webb,H, Georgi, N., Crowley,P.B., McIntosh,L.P., Nielsen,J.E. (2010) 'Titration_DB: Storage analysis of NMR-monitored protein pH titration curves'. Proteins: Structure, Function And Bioformatics, 78 :843-857 [Details]
(2009) 'Metal-Mediated Self-Assembly of a beta-Sandwich Protein'
Crowley, PB;Matias, PM;Khan, AR;Roessle, M;Svergun, DI (2009) 'Metal-Mediated Self-Assembly of a beta-Sandwich Protein'. Chemistry-A European Journal, 15 :12672-12680 [DOI] [Details]
(2009) 'Metal-Mediated Self-Assembly of a beta-Sandwich Protein'
Crowley, PB,Matias, PM,Khan, AR,Roessle, M,Svergun, DI (2009) 'Metal-Mediated Self-Assembly of a beta-Sandwich Protein'. Chemistry-A European Journal, 15 :12672-12680 [DOI] [Details]
(2008) 'Interaction tuning of the active site properties of metalloproteins'
Yanagisawa, S.,Dennison, C.,Crowley, P.B.,Firbank, S.J.,Lawler, A.T.,Hunter, D.M.,McFarlane, W.,Li, C.,Kohzuma, T.,Banfield, M.J. (2008) 'Interaction tuning of the active site properties of metalloproteins'. Journal of the American Chemical Society, 130 (46) [Details]
(2008) 'Regulation of protein function: Crystal packing interfaces and conformational dimerization'
Crowley, P.B.,Matias, P.M.,Mi, H.,Firbank, S.J.,Banfield, M.J.,Dennison, C. (2008) 'Regulation of protein function: Crystal packing interfaces and conformational dimerization'. Biochemistry, 47 (25) [Details]
(2008) 'Quaternary Structure of Flavorubredoxin as Revealed by Synchrotron Radiation Small-Angle X-Ray Scattering'
Petoukhov, M.V.,Vicente, J.B.,Crowley, P.B.,Carrondo, M.A.,Teixeira, M.,Svergun, D.I. (2008) 'Quaternary Structure of Flavorubredoxin as Revealed by Synchrotron Radiation Small-Angle X-Ray Scattering'. Structure, 16 (9) [Details]
(2008) 'Protein surface recognition: Structural characterisation of cytochrome c-porphyrin complexes'
Crowley,P.B.,Ganji, P.,Ibrahim, H. (2008) 'Protein surface recognition: Structural characterisation of cytochrome c-porphyrin complexes'. ChemBioChem, 9 (7) [Details]
(2008) 'NMR spectroscopy revceals cytochrome c-poly(ethylene glycol) interactions'
Crowley,P.B.,Brett, K.,Muldoon, J. (2008) 'NMR spectroscopy revceals cytochrome c-poly(ethylene glycol) interactions'. ChemBioChem, 9 (5) [Details]
(2007) 'Transient protein interactions of cytochrome f and the phytocyanin umecyanin'
Sato,K.,Crowley,P.B.,Dennison,C. (2007) 'Transient protein interactions of cytochrome f and the phytocyanin umecyanin'. ChemBioChem, 8 :732-735 [Details]
(2005) 'Transient homodimer interactions studied using the electron self-exchange reaction'
Sato, K.,Crowley, P.B.,Dennison, C. (2005) 'Transient homodimer interactions studied using the electron self-exchange reaction'. Journal of Biological Chemistry, 280 (19) [Details]
(2005) 'Different modes of interaction in cyanobacterial complexes of plastocyanin and cytochrome f'
Diaz-Moreno,I.,Diaz-Quintana,A.,De La Rosa, M.A.,Crowley,P.B.,Ubbink, M. (2005) 'Different modes of interaction in cyanobacterial complexes of plastocyanin and cytochrome f'. Biochemistry, 44 (9) [Details]
(2005) 'Cation-pi interactions in protein-protein interfaces'
Crowley,P.B.,Golovin,A. (2005) 'Cation-pi interactions in protein-protein interfaces'. Proteins: Structure, Function And Bioformatics, 59 :231-239 [Details]
(2004) 'The Architecture of the Binding Site in Redox Protein Complexes: Implications for Fast Dissociation'
Crowley,P.B.,Carrondo, M.A. (2004) 'The Architecture of the Binding Site in Redox Protein Complexes: Implications for Fast Dissociation'. Proteins: Structure, Function and Genetics, 55 (3) [Details]
(2004) 'The parsley plastocyanin-turnip cytochrome f complex: A structurally distorted but kinetically functional acidic patch'
Crowley, P.B.,Hunter, D.M.,Sato, K.,McFarlane, W.,Dennison, C. (2004) 'The parsley plastocyanin-turnip cytochrome f complex: A structurally distorted but kinetically functional acidic patch'. Biochemical Journal, 378 (1) [Details]
(2003) 'Close Encounters of the Transient Kind: Protein Interactions in the Photosynthetic Redox Chain Investigated by NMR Spectroscopy'
Crowley, P.B.,Ubbink, M. (2003) 'Close Encounters of the Transient Kind: Protein Interactions in the Photosynthetic Redox Chain Investigated by NMR Spectroscopy'. Accounts of Chemical Research, 36 (10) [Details]
(2002) 'The ternary complex of cytochrome f and cytochrome c: Identification of a second binding site and competition for plastocyanin binding'
Crowley, P.B.,Rabe, K.S.,Worrall, J.A.R.,Canters, G.W.,Ubbink, M. (2002) 'The ternary complex of cytochrome f and cytochrome c: Identification of a second binding site and competition for plastocyanin binding'. ChemBioChem, 3 (6) [Details]
(2002) 'The interactions of cyanobacterial cytochrome c6 and cytochrome f, characterized by NMR'
Crowley, P.B.,Diaz-Quintana, A.,Molina-Heredia, F.P.,Nieto, P.,Sutter, M.,Haehnel, W.,De la Rosa, M.A.,Ubbink, M. (2002) 'The interactions of cyanobacterial cytochrome c6 and cytochrome f, characterized by NMR'. Journal of Biological Chemistry, 277 (50) [Details]
(2002) 'Plastocyanin-cytochrome f interactions: The influence of hydrophobic patch mutations studied by NMR spectroscopy'
Crowley,P.B.,Vintonenko, N.,Bullerjahn,G.S,Ubbink,M. (2002) 'Plastocyanin-cytochrome f interactions: The influence of hydrophobic patch mutations studied by NMR spectroscopy'. Biochemistry, 41 :15698-15705 [Details]
(2002) 'Co-operative ortho-effects on the Wittig reaction Interpretation of stereoselectivity in the reaction of ortho-halo-substituted benzaldehydes and benzylidenetriphenyl-phosphoranes'
Dunne,E.C.,Coyne,E.J.,Crowley,P.B.,Gilheany,D.G. (2002) 'Co-operative ortho-effects on the Wittig reaction Interpretation of stereoselectivity in the reaction of ortho-halo-substituted benzaldehydes and benzylidenetriphenyl-phosphoranes'. Tetrahedron Lett, 43 :2449-2453 [Details]
(2002) 'Myoglobin and cytochrome b5: A nuclear magnetic resonance study of a highly dynamic protein complex'
Worrall, J.A.R.,Liu, Y.,Crowley, P.B.,Nocek, J.M.,Hoffman, B.M.,Ubbink, M. (2002) 'Myoglobin and cytochrome b5: A nuclear magnetic resonance study of a highly dynamic protein complex'. Biochemistry, 41 (39) [Details]
(2001) 'Hydrophobic interactions in a cyanobacterial plastocyanin - Cytochrome f complex'
Crowley,P.B.,Otting, G.,Schlarb-Ridley, B.G.,Canters, G.W.,Ubbink, M. (2001) 'Hydrophobic interactions in a cyanobacterial plastocyanin - Cytochrome f complex'. Journal of the American Chemical Society, 123 (43) [Details]
(2000) 'Angle restraints in protein backbones from dipole-dipole cross-correlation between 1HN-15N and 1HN-1H vectors'
Crowley, P.,Ubbink,M.,Otting.G. (2000) 'Angle restraints in protein backbones from dipole-dipole cross-correlation between 1HN-15N and 1HN-1H vectors'. Journal Of The American Chemical Society, 122 :2968-2969 [Details]

Books

  Year Publication
(2020) Supramolecular Protein Chemistry: Assembly, Architecture and Application.
Crowley P.B. (2020) Supramolecular Protein Chemistry: Assembly, Architecture and Application. Cambridge, UK: RSC. [DOI] [Details]

Abstract

  Year Publication
(2015) Effects of cell-like infrastructures on transient protein interactions.
Kyne, C,Crowley, P (2015) Effects of cell-like infrastructures on transient protein interactions. Abstract [Details]
(2015) Selective Recognition and Assembly in Protein-Small molecule Interactions.
Doolan, AM,Jurgens, MC,Khan, AR,Crowley, PB (2015) Selective Recognition and Assembly in Protein-Small molecule Interactions. Abstract [Details]

Editorial

  Year Publication
(2017) Structural studies of calixarene-mediated noncovalent PEGylation.
Mummidivarapu, VVS,Rennie, ML,Crowley, PB (2017) Structural studies of calixarene-mediated noncovalent PEGylation. Editorial [Details]
(2017) NMR spectroscopic analysis of protein-surface interactions - The effect of PEGylation.
Ramberg, KO,Antonik, PM,Crowley, PB (2017) NMR spectroscopic analysis of protein-surface interactions - The effect of PEGylation. Editorial [Details]

Reviews

  Year Publication
(2016) Grasping the nature of the cell interior: from Physiological Chemistry to Chemical Biology.
Kyne, C;Crowley, PB (2016) Grasping the nature of the cell interior: from Physiological Chemistry to Chemical Biology. HOBOKEN: WILEY Reviews [DOI] [Details]
(2014) Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs).
Theillet, FX;Binolfi, A;Frembgen-Kesner, T;Hingorani, K;Sarkar, M;Kyne, C;Li, CG;Crowley, PB;Gierasch, L;Pielak, GJ;Elcock, AH;Gershenson, A;Selenko, P (2014) Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs). WASHINGTON: AMER CHEMICAL SOC Reviews [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2021 SSPC Director's Award for Award for Research Article of the Year SSPC - Science Foundation Ireland Research Centre for Pharmaceuticals

Professional Associations

  Association Function From / To
Royal Society of Chemistry Fellow /
ACS Crystal Growth & Design Editorial Advisory Board /
EuChemS - Life Science division National representative /
British Biophysical Society Organising committee /
Institute of Chemistry of Ireland Galway representative /
Groupement AMPERE Committee member /

Committees

  Committee Function From / To
SBCS Education & Students Committee Representng GY318 BSc Biopharmaceutical Chemistry /

Education

  Year Institution Qualification Subject
1998 University College Dublin BSc Chemistry
2002 Leiden University PhD Biophysics

Teaching Interests

Peter contributes to various lecture and practical courses in GY301 and GY318, including:

CH101 General chemistry
CH202 Organic Chemistry practical classes
CH333 Experimental Chemistry I
CH3101 Computers and Chemical Research
CH311 Organic Chemistry
CH4101 Research project
CH4115 Biopharmaceutical Chemistry
CH4116 Biopharmaceutical Dissertation
CH4117 Biopharmaceutical Work Placement
CH438 Bioorganic Chemistry











Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2014 Roise Mc Govern PhD Y
2015 Madeleine Mallon Msc Y
2015 Giada Cattani PhD Y

Internal Collaborators

  Name Description of Collaboration
Internal Collaborators
Dr. Andrew FlausProf. Kevin Sullivan

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
External Collaborators
Prof. Christopher Dennison (Newcastle University) Prof. Jan van Hest (Radboud University Nijmegen) Dr. Amir Khan (Trinity College Dublin) Dr. Jens Nielsen (University College Dublin) Prof. Gary Pielak (University of North Carolina at Chapel Hill) Dr. Dmitri Svergun (EMBL, Hamburg)