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Professor Laoise McNamara

B.ENG, Ph.D, DIP STAT

 
researcher
 

Biography

Research Career:
 
2020- present: Established Professor in Biomedical Engineering

2016- 2020: Personal Professor in Biomedical Engineering

2014- 2016: Lecturer in Biomedical Engineering, College of Engineering and Informatics, NUI Galway

2009- 2014: SFI Stokes Lecturer: College of Engineering and Informatics, NUI Galway

2007- 2009: Lecturer: School of Engineering Sciences, University of Southampton, UK

2005- 2007: Lecturer (Fixed term): Dept of Mechanical and Biomedical Engineering, NUI Galway

2004- 2005: Postdoctoral Researcher: Mount Sinai School of Medicine, New York, USA

Professor Laoise McNamara is a Personal Professor in Biomedical Engineering at the National University of Ireland, Galway. She established the Mechanobiology and Medical Device Research group at NUI Galway in 2009, which is currently comprised of 14 researchers. The MMDRG research group (www.mechanobiology.ie) use multidisciplinary approaches to understand mechanobiology and how this process contributes to bone development and osteoporosis. They have developed novel multiphysics and multiscale computational modelling techniques and have applied these methods to derive an understanding of the mechanical stimuli that bone cells experience in vivo in healthy and osteoporotic bone tissue. Her research group have uncovered changes in bone mechanobiology during osteoporosis. Her research has been applied to understand the role of mechanical stimulation in bone regeneration and she develops in vitro tissue regeneration strategies that exploit mechanobiological responses to overcome challenges in the field of bone tissue engineering. Professor McNamara’s research is informing the generation of novel therapeutic approaches for osteoporosis. Professor McNamara collaborates with Stryker, Boston Scientific and Medtronic applying her expertise in computational and experimental biomechanics to the pre-clinical assessment of surgical and minimally invasive medical devices. Professor McNamara was awarded an Irish Research Council (IRC) Laureate Award in 2018, the SFI Investigators Grant in 2015 and a European Research Council Starting Independent Researcher Award in 2011 along with various other Health Research Board, SFI and Irish Research Council funding. She has been awarded the ‘Bone and Joint Decade’ New Investigator Award by the Orthopaedic Research Society, and the Harold B. Frost Young Investigator Award by the American Society for Bone and Mineral Research (ASBMR). She has published more than 70 research articles in various high Impact Factor journals; PNAS, European Cells and Materials, the Journal of the Royal Society Interface, Bone, Tissue Engineering Part A and the Biophysical Journal, among many others. She is a reviewer for over 20 peer-reviewed international journals. She has also acted as a Royal Academy of Engineering (UK) reviewer for the Irish Research Council for Science and Engineering Technology (IRCSET) Postdoctoral Fellowships scheme. Professor McNamara a member of the Executive board and Platform Lead for the Science Foundation Ireland (SFI) funded Centre for Research in Medical Devices (CURAM) and is the Vice Dean for Recruitment and Internationalisation in the College of Engineering and Informatics at NUI Galway.

Research Interests

The primary objective of the research in Professor McNamara's group is to delineate the normal mechanosensory and signalling mechanisms of bone cells. The secondary objective is to determine whether bone tissue mechanics or mechanobiology are impaired during osteoporosis. The final objective is to develop in vitro approaches that can enhance bone tissue regeneration and thereby advance treatment of bone pathologies. The research expertise in Professor McNamara's group incorporates experimental and computational techniques including micromechanical testing, finite element modelling and theoretical mechano-regulation theories. In addition her group uses in vitro cell culture, advanced microscopy and immunohistochemistry techniques to characterise bone cell biology. Using such methods we focus on:

  • Mechanical properties of bone tissue during osteoporosis
  • Bone mineral composition during osteoporosis
  • Identifying the noncollagenous components of bone tissue during disease
  • Identifying bone cell mechanotransduction machinery in vivo and in vitro
  • Characterising bone cell responses to their mechanical environment in vitro
  • Bone mechanobiology during disease 
  • Developing novel mechanobiology-based approaches to bone tissue regeneration.
 
In addition to these studies Professor McNamara has research collaborations with Stryker Instruments and Boston Scientific. Studies with Stryker Instruments aim to advance understanding of the mechanical and thermal properties of bone and cutting tool materials during surgical cutting procedures. Studies with Boston Scientific aim to advance understanding of transcatheter bioprostheses using experimental approaches and computational modelling

Research Projects

  Project Start Date End Date
Mechanobiologically mimetic model systems for study of Bone disease (MEMETic) 01-SEP-20 31-AUG-30
IRC Laureate - Mechanobiological model systems for bone metastases mimetics 01-SEP-18 31-AUG-22

Peer Reviewed Journals

  Year Publication
(2012) 'Multiscale Modelling of Bone: Understanding Tissue Mechanics and Cell Mechanobiology'
Vaughan, Ted J and McNamara, Laoise M (2012) 'Multiscale Modelling of Bone: Understanding Tissue Mechanics and Cell Mechanobiology'. Journal of Biomechanics, (45) [Details]
(2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'
Verbruggen, Stefaan W and Vaughan, Ted J and McNamara, Laoise M (2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'. Journal of the Royal Society Interface, 9 (75):2735-2744 [Details]
(2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'
Vaughan, Ted J and McCarthy, Conor T and McNamara, Laoise M (2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'. Journal of the mechanical behavior of biomedical materials, 12 :50-62 [Details]
(2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'
Vaughan, Ted J and Verbruggen, Stefaan W and McNamara, Laoise M (2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'. International journal for numerical methods in biomedical engineering, 29 (12):1361-1372 [Details]
(2013) 'A fluid--structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'
Vaughan, TJ and Haugh, MG and McNamara, LM (2013) 'A fluid--structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'. Journal of The Royal Society Interface, 10 (81) [Details]
(2014) 'The Role of Integrin $\alpha$V$\beta$3 in Osteocyte Mechanotransduction'
Haugh, Matthew G and Vaughan, Ted J and McNamara, Laoise M (2014) 'The Role of Integrin $\alpha$V$\beta$3 in Osteocyte Mechanotransduction'. Journal of the mechanical behavior of biomedical materials, [Details]
(2014) 'How bone tissue and cells experience elevated temperatures during orthopaedic cutting: an experimental and computational investigation'
Dolan, Eimear B and Vaughan, Ted J and Niebur, Glen L and Casey, Conor and Tallon, David and McNamara, Laoise M (2014) 'How bone tissue and cells experience elevated temperatures during orthopaedic cutting: an experimental and computational investigation'. Journal of biomechanical engineering, 136 (2) [Details]
(2014) 'Fluid flow in the osteocyte mechanical environment: a fluid--structure interaction approach'
Verbruggen, Stefaan W and Vaughan, Ted J and McNamara, Laoise M (2014) 'Fluid flow in the osteocyte mechanical environment: a fluid--structure interaction approach'. Biomechanics and modeling in mechanobiology, 13 (1):85-97 [Details]
(2015) 'The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior'
Mullen, Conleth A and Vaughan, Ted J and Billiar, Kristen L and McNamara, Laoise M (2015) 'The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior'. Biophysical journal, 108 (7):1604-1612 [Details]
(2014) 'Cell morphology and focal adhesion location alters internal cell stress'
Mullen, CA and Vaughan, TJ and Voisin, MC and Brennan, MA and Layrolle, P and McNamara, LM (2014) 'Cell morphology and focal adhesion location alters internal cell stress'. Journal of The Royal Society Interface, 11 (101) [Details]
(2014) 'Simulation of self expanding transcatheter aortic valve in a realistic aortic root: implications of deployment geometry on leaflet deformation'
Gunning, Paul S and Vaughan, Ted J and McNamara, Laoise M (2014) 'Simulation of self expanding transcatheter aortic valve in a realistic aortic root: implications of deployment geometry on leaflet deformation'. Annals of biomedical engineering, 42 :1989-2001 [Details]
(2015) 'The in situ mechanics of trabecular bone marrow: the potential for mechanobiological response'
Metzger, Thomas A and Kreipke, Tyler C and Vaughan, Ted J and McNamara, Laoise M and Niebur, Glen L (2015) 'The in situ mechanics of trabecular bone marrow: the potential for mechanobiological response'. Journal of biomechanical engineering, 137 (1) [Details]
(2015) 'Bone cell mechanosensation of fluid flow stimulation: a fluid--structure interaction model characterising the role integrin attachments and primary cilia'
Vaughan, TJ and Mullen, CA and Verbruggen, SW and McNamara, LM (2015) 'Bone cell mechanosensation of fluid flow stimulation: a fluid--structure interaction model characterising the role integrin attachments and primary cilia'. Biomechanics and modeling in mechanobiology, 14 :703-718 [Details]
(2015) 'Multiscale fluid--structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold'
Zhao, Feihu and Vaughan, Ted J and Mcnamara, Laoise M (2015) 'Multiscale fluid--structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold'. Biomechanics and modeling in mechanobiology, 14 :231-243 [Details]
(2015) 'Multiscale modeling of trabecular bone marrow: understanding the micromechanical environment of mesenchymal stem cells during osteoporosis'
Vaughan, TJ and Voisin, M and Niebur, GL and McNamara, LM (2015) 'Multiscale modeling of trabecular bone marrow: understanding the micromechanical environment of mesenchymal stem cells during osteoporosis'. Journal of biomechanical engineering, 137 (1) [Details]
(2016) 'Mechanisms of osteocyte stimulation in osteoporosis'
Verbruggen, Stefaan W and Vaughan, Ted J and McNamara, Laoise M (2016) 'Mechanisms of osteocyte stimulation in osteoporosis'. Journal of the mechanical behavior of biomedical materials, 62 :158-168 [Details]
(2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'
Zhao, Feihu and Vaughan, Ted J and McNamara, Laoise M (2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'. Biomechanics and modeling in mechanobiology, 15 :561-577 [Details]
(2017) 'A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading'
Zhao, Feihu and Vaughan, Ted J and Mc Garrigle, Myles J and McNamara, Laoise M (2017) 'A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading'. Computers in Biology and Medicine, 89 :181-189 [Details]
(2017) 'Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur'
Metzger, Thomas A and Vaughan, Ted J and McNamara, Laoise M and Niebur, Glen L (2017) 'Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur'. Biomechanics and Modeling in Mechanobiology, 16 :841-850 [Details]
(2018) 'Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates'
Haugh, Matthew G and Vaughan, Ted J and Madl, Christopher M and Raftery, Rosanne M and McNamara, Laoise M and O'Brien, Fergal J and Heilshorn, Sarah C (2018) 'Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates'. Biomaterials, 171 :23-33 [Details]
(2018) 'In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm'
Zhao, Feihu and Mc Garrigle, Myles J and Vaughan, Ted J and McNamara, Laoise M (2018) 'In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm'. Biomechanics and Modeling in Mechanobiology, 17 :5-18 [Details]
(2022) 'Temporal and spatial changes in bone mineral content and mechanical properties during breast-cancer bone metastases'
Verbruggen ASK, McCarthy EC, Dwyer RM, McNamara LM (2022) 'Temporal and spatial changes in bone mineral content and mechanical properties during breast-cancer bone metastases'. Bone Reports, 17 [DOI] [Details]
(2020) 'Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration'
Naqvi SM;McNamara LM; (2020) 'Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration'. Frontiers in Bioengineering and Biotechnology, 8 [DOI] [Details]
(2020) 'Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture'
Curtis, KJ;Schiavi, J;Mc Garrigle, MJ;Kumar, V;McNamara, LM;Niebur, GL (2020) 'Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture'. Journal Of The Royal Society Interface, 17 [DOI] [Details]
(2020) 'Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture'
Curtis, KJ,Schiavi, J,Mc Garrigle, MJ,Kumar, V,McNamara, LM,Niebur, GL (2020) 'Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture'. Journal Of The Royal Society Interface, 17 [DOI] [Details]
(2020) 'Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes'
Allison, H;Holdsworth, G;McNamara, LM (2020) 'Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes'. Bmc Molecular And Cell Biology, 21 [DOI] [Details]
(2020) 'ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts'
Simfia, I,Schiavi, J,McNamara, LM (2020) 'ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts'. Experimental Cell Research, 396 [DOI] [Details]
(2020) 'Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes'
Allison, H,Holdsworth, G,McNamara, LM (2020) 'Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes'. Bmc Molecular And Cell Biology, 21 [DOI] [Details]
(2020) 'ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts'
Simfia I;Schiavi J;McNamara LM; (2020) 'ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts'. Experimental Cell Research, 396 (1) [DOI] [Details]
(2020) 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency'
Naqvi, SM;Perez, JAP;Kumar, V;Verbruggen, ASK;McNamara, LM (2020) 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency'. Frontiers in Bioengineering and Biotechnology, 8 [DOI] [Details]
(2020) 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency'
Naqvi, SM,Perez, JAP,Kumar, V,Verbruggen, ASK,McNamara, LM (2020) 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency'. Frontiers in Bioengineering and Biotechnology, 8 [DOI] [Details]
(2020) 'Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting'
Casey, VJ;Martin, C;Curtin, P;Buckley, K;McNamara, LM (2020) 'Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting'. Annals Of Biomedical Engineering, [DOI] [Details]
(2020) 'Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting'
Casey, VJ,Martin, C,Curtin, P,Buckley, K,McNamara, LM (2020) 'Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting'. Annals Of Biomedical Engineering, [DOI] [Details]
(2020) 'Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study'
Watson L;Chen XZ;Ryan AE;Fleming Á;Carbin A;O'Flynn L;Loftus PG;Horan E;Connolly D;McDonnell P;McNamara LM;O'Brien T;Coleman CM; (2020) 'Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study'. Cells, 9 (6):1-20 [DOI] [Details]
(2020) 'Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study'
Parle E;Tio S;Behre A;Carey JJ;Murphy CG;O'Brien TF;Curtin WA;Kearns SR;McCabe JP;Coleman CM;Vaughan TJ;McNamara LM; (2020) 'Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study'. Jbmr Plus, 4 (2) [DOI] [Details]
(2020) 'Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model'
Simfia, I;Schiavi, J;Mcnamara, LM (2020) 'Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model'. Experimental Cell Research, 392 [DOI] [Details]
(2020) 'Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model'
Simfia, I,Schiavi, J,Mcnamara, LM (2020) 'Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model'. Experimental Cell Research, 392 [DOI] [Details]
(2020) 'A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect'
Freeman, FE,Brennan, MA,Browe, DC,Renaud, A,De Lima, J,Kelly, DJ,McNamara, LM,Layrolle, P (2020) 'A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect'. Frontiers in Bioengineering and Biotechnology, 8 [DOI] [Details]
(2020) 'A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect'
Freeman, FE;Brennan, MA;Browe, DC;Renaud, A;De Lima, J;Kelly, DJ;McNamara, LM;Layrolle, P (2020) 'A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect'. Frontiers in Bioengineering and Biotechnology, 8 [DOI] [Details]
(2019) 'Secondary alterations in bone mineralisation and trabecular thickening occur after long-term estrogen deficiency in ovariectomised rat tibiae, which do not coincide with initial rapid bone loss'
O'Sullivan, LM,Allison, H,Parle, EE,Schiavi, J,McNamara, LM (2019) 'Secondary alterations in bone mineralisation and trabecular thickening occur after long-term estrogen deficiency in ovariectomised rat tibiae, which do not coincide with initial rapid bone loss'. Osteoporosis International, [DOI] [Details]
(2019) 'The impact of implantation depth of the Lotus valve on mechanical stress in close proximity to the bundle of His'
McGee, OM,Gunning, PS,McNamara, A,McNamara, LM (2019) 'The impact of implantation depth of the Lotus valve on mechanical stress in close proximity to the bundle of His'. Biomechanics And Modeling In Mechanobiology, 18 :79-88 [DOI] [Details]
(2019) 'Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency'
Allison, H;McNamara, LM (2019) 'Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency'. American Journal Of Physiology: Cell Physiology, 317 :969-982 [DOI] [Details]
(2019) 'An in vitro model quantifying the effect of calcification on the tissue-stent interaction in a stenosed aortic root'
McGee, OM,Sun, W,McNamara, LM (2019) 'An in vitro model quantifying the effect of calcification on the tissue-stent interaction in a stenosed aortic root'. Journal Of Biomechanics, 82 :109-115 [DOI] [Details]
(2019) 'Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency'
Allison, H,McNamara, LM (2019) 'Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency'. American Journal Of Physiology-Cell Physiology, 317 :969-982 [DOI] [Details]
(2019) 'Secondary alterations in bone mineralisation and trabecular thickening occur after long-term estrogen deficiency in ovariectomised rat tibiae, which do not coincide with initial rapid bone loss'
O'Sullivan, LM;Allison, H;Parle, EE;Schiavi, J;McNamara, LM (2019) 'Secondary alterations in bone mineralisation and trabecular thickening occur after long-term estrogen deficiency in ovariectomised rat tibiae, which do not coincide with initial rapid bone loss'. Osteoporosis International, [DOI] [Details]
(2019) 'Estrogen deficiency impairs integrin alpha(v)beta(3)-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling'
Geoghegan, IP,Hoey, DA,McNamara, LM (2019) 'Estrogen deficiency impairs integrin alpha(v)beta(3)-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling'. Scientific Reports, 9 [DOI] [ARAN Link] [Details]
(2018) 'In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm'
Zhao, FH,Mc Garrigle, MJ,Vaughan, TJ,McNamara, LM (2018) 'In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm'. Biomechanics And Modeling In Mechanobiology, 17 :5-18 [DOI] [Details]
(2018) 'Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates'
Haugh, MG,Vaughan, TJ,Madl, CM,Raftery, RM,McNamara, LM,O'Brien, FJ,Heilshorn, SC (2018) 'Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates'. Biomaterials, 171 :23-33 [DOI] [Details]
(2017) 'A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading'
Zhao, FH,Vaughan, TJ,Mc Garrigle, MJ,McNamara, LM (2017) 'A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading'. Computers in biology and medicine, 89 :181-189 [DOI] [Details]
(2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'
Freeman, F. E.,Schiavi, J.,Brennan, M. A.,Owens, P.,Layrolle, P.,McNamara, L. M. (2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'. Tissue Eng Part A, [Details]
(2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'
Freeman, FE,Schiavi, J,Brennan, MA,Owens, P,Layrolle, P,McNamara, LM (2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'. Tissue Engineering Part A, 23 :1466-1478 [DOI] [Details]
(2017) 'Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur'
Metzger, TA,Vaughan, TJ,McNamara, LM,Niebur, GL (2017) 'Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur'. Biomechanics And Modeling In Mechanobiology, 16 :841-850 [DOI] [Details]
(2017) 'The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids'
Griffin, F.E.; Schiavi, J.; McDevitt, T.C.; McGarry, J.P.; McNamara, L.M. (2017) 'The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids'. Journal Of Biomechanics, 59 :71-79 [DOI] [Details]
(2017) 'The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells'
Virjula, S,Zhao, FH,Leivo, J,Vanhatupa, S,Kreutzer, J,Vaughan, TJ,Honkala, AM,Viehrig, M,Mullen, CA,Kallio, P,McNamara, LM,Miettinen, S (2017) 'The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells'. Journal Of The Mechanical Behavior Of Biomedical Materials, 72 :38-48 [DOI] [Details]
(2017) 'Estrogen deficiency attenuates fluid flow-induced [Ca2+](i) oscillations and mechanoresponsiveness of MLO-Y4 osteocytes'
Deepak, V,Kayastha, P,McNamara, LM (2017) 'Estrogen deficiency attenuates fluid flow-induced [Ca2+](i) oscillations and mechanoresponsiveness of MLO-Y4 osteocytes'. Faseb Journal, 31 :3027-3039 [DOI] [Details]
(2017) 'The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids'
Griffin, FE,Schiavi, J,McDevitt, TC,McGarry, JP,McNamara, LM (2017) 'The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids'. Journal Of Biomechanics, 59 :71-79 [DOI] [Details]
(2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'
Freeman, FE;Schiavi, J;Brennan, MA;Owens, P;Layrolle, P;McNamara, LM (2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'. Tissue Engineering Part A, 23 :1466-1478 [DOI] [Details]
(2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human MSCs'
Freeman FE1, Schiavi J2, Brennan MA, Owens P, Layrolle P, McNamara L. (2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human MSCs'. Tissue Engineering Part A, [DOI] [Details]
(2016) 'Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture'
Coughlin, T. R.,Schiavi, J.,Alyssa Varsanik, M.,Voisin, M.,Birmingham, E.,Haugh, M. G.,McNamara, L. M.,Niebur, G. L. (2016) 'Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture'. Eur Cell Mater, 32 :111-22 [Details]
(2016) 'Bone mechanical properties and changes with osteoporosis'
Osterhoff, G,Morgan, EF,Shefelbine, SJ,Karim, L,McNamara, LM,Augat, P (2016) 'Bone mechanical properties and changes with osteoporosis'. Injury-International Journal Of The Care Of The Injured, 47 :11-20 [Details]
(2016) 'Bone mechanical properties and changes with osteoporosis'
Osterhoff, G;Morgan, EF;Shefelbine, SJ;Karim, L;McNamara, LM;Augat, P (2016) 'Bone mechanical properties and changes with osteoporosis'. Injury-International Journal Of The Care Of The Injured, 47 :11-20 [Details]
(2016) 'PRIMARY CILIA EXPRESSION IN BONE MARROW IN RESPONSE TO MECHANICAL STIMULATION IN EXPLANT BIOREACTOR CULTURE'
Coughlin, TR,Schiavi, J,Varsanik, MA,Voisin, M,Birmingham, E,Haugh, MG,McNamara, LM,Niebur, GL (2016) 'PRIMARY CILIA EXPRESSION IN BONE MARROW IN RESPONSE TO MECHANICAL STIMULATION IN EXPLANT BIOREACTOR CULTURE'. European Cells & Materials, 32 :111-122 [DOI] [Details]
(2016) 'Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo'
Dolan, EB,Tallon, D,Cheung, WY,Schaffler, MB,Kennedy, OD,McNamara, LM (2016) 'Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo'. Journal Of The Royal Society Interface, 13 [DOI] [Details]
(2016) 'Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo'
Dolan, EB;Tallon, D;Cheung, WY;Schaffler, MB;Kennedy, OD;McNamara, LM (2016) 'Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo'. Journal Of The Royal Society Interface, 13 [DOI] [Details]
(2016) 'Mechanisms of osteocyte stimulation in osteoporosis'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2016) 'Mechanisms of osteocyte stimulation in osteoporosis'. Journal Of The Mechanical Behavior Of Biomedical Materials, 62 :158-168 [DOI] [ARAN Link] [Details]
(2016) 'OSTEOCYTE DIFFERENTIATION AND THE FORMATION OF AN INTERCONNECTED CELLULAR NETWORK IN VITRO'
Mc Garrigle, MJ,Mullen, CA,Haugh, MG,Voisin, MC,McNamara, LM (2016) 'OSTEOCYTE DIFFERENTIATION AND THE FORMATION OF AN INTERCONNECTED CELLULAR NETWORK IN VITRO'. European Cells & Materials, 31 :323-340 [DOI] [ARAN Link] [Details]
(2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'
Zhao, FH,Vaughan, TJ,McNamara, LM (2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'. Biomechanics And Modeling In Mechanobiology, 15 :561-577 [DOI] [ARAN Link] [Details]
(2016) 'PRIMARY CILIA EXPRESSION IN BONE MARROW IN RESPONSE TO MECHANICAL STIMULATION IN EXPLANT BIOREACTOR CULTURE'
Coughlin, TR;Schiavi, J;Varsanik, MA;Voisin, M;Birmingham, E;Haugh, MG;McNamara, LM;Niebur, GL (2016) 'PRIMARY CILIA EXPRESSION IN BONE MARROW IN RESPONSE TO MECHANICAL STIMULATION IN EXPLANT BIOREACTOR CULTURE'. European Cells & Materials, 32 :111-122 [DOI] [ARAN Link] [Details]
(2016) 'An Experimental and Computational Investigation of Bone Formation in Mechanically Loaded Trabecular Bone Explants'
Birmingham, E,Niebur, GL,McNamara, LM,McHugh, PE (2016) 'An Experimental and Computational Investigation of Bone Formation in Mechanically Loaded Trabecular Bone Explants'. Annals Of Biomedical Engineering, 44 :1191-1203 [DOI] [Details]
(2015) 'Multiscale Modeling of Trabecular Bone Marrow: Understanding the Micromechanical Environment of Mesenchymal Stem Cells During Osteoporosis'
Vaughan, TJ,Voisin, M,Niebur, GL,McNamara, LM (2015) 'Multiscale Modeling of Trabecular Bone Marrow: Understanding the Micromechanical Environment of Mesenchymal Stem Cells During Osteoporosis'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 137 [DOI] [Details]
(2015) 'The In Situ Mechanics of Trabecular Bone Marrow: The Potential for Mechanobiological Response'
Metzger, TA,Kreipke, TC,Vaughan, TJ,McNamara, LM,Niebur, GL (2015) 'The In Situ Mechanics of Trabecular Bone Marrow: The Potential for Mechanobiological Response'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 137 [DOI] [Details]
(2015) 'The role of integrin alpha(v)beta(3) in osteocyte mechanotransduction'
Haugh, MG,Vaughan, TJ,McNamara, LM (2015) 'The role of integrin alpha(v)beta(3) in osteocyte mechanotransduction'. Journal Of The Mechanical Behavior Of Biomedical Materials, 42 :67-75 [DOI] [ARAN Link] [Details]
(2015) 'Primary Cilia Exist in a Small Fraction of Cells in Trabecular Bone and Marrow'
Coughlin, TR,Voisin, M,Schaffler, MB,Niebur, GL,McNamara, LM (2015) 'Primary Cilia Exist in a Small Fraction of Cells in Trabecular Bone and Marrow'. Calcified Tissue International, 96 :65-72 [DOI] [ARAN Link] [Details]
(2015) 'The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior'
Mullen, CA,Vaughan, TJ,Billiar, KL,McNamara, LM (2015) 'The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior'. Biophysical journal, 108 :1604-1612 [DOI] [ARAN Link] [Details]
(2015) 'Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants'
Birmingham, E., Kreipke, T.C., Dolan, E.C., Coughlin, T.R., Owens, P., McNamara, L.M., Niebur, G.l., McHugh, P.E. (2015) 'Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants'. Annals Of Biomedical Engineering, 43 (4):1036-1050 [ARAN Link] [Details]
(2015) 'Bone cell mechanosensation of fluid flow stimulation: a fluid-structure interaction model characterising the role integrin attachments and primary cilia'
Vaughan, TJ,Mullen, CA,Verbruggen, SW,McNamara, LM (2015) 'Bone cell mechanosensation of fluid flow stimulation: a fluid-structure interaction model characterising the role integrin attachments and primary cilia'. Biomechanics And Modeling In Mechanobiology, 14 :703-718 [DOI] [Details]
(2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'
Dolan, EB,Haugh, MG,Voisin, MC,Tallon, D,McNamara, LM (2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'. Plos One, 10 [DOI] [ARAN Link] [Details]
(2015) 'Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold'
Zhao, FH,Vaughan, TJ,Mcnamara, LM (2015) 'Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold'. Biomechanics And Modeling In Mechanobiology, 14 :231-243 [DOI] [ARAN Link] [Details]
(2015) 'An In Vitro Bone Tissue Regeneration Strategy Combining Chondrogenic and Vascular Priming Enhances the Mineralization Potential of Mesenchymal Stem Cells In Vitro While Also Allowing for Vessel Formation'
Freeman, FE,Haugh, MG,McNamara, LM (2015) 'An In Vitro Bone Tissue Regeneration Strategy Combining Chondrogenic and Vascular Priming Enhances the Mineralization Potential of Mesenchymal Stem Cells In Vitro While Also Allowing for Vessel Formation'. Tissue Engineering Part A, 21 :1320-1332 [DOI] [ARAN Link] [Details]
(2015) 'Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis'
Verbruggen, SW,Mc Garrigle, MJ,Haugh, MG,Voisin, MC,McNamara, LM (2015) 'Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis'. Biophysical journal, 108 :1587-1598 [DOI] [ARAN Link] [Details]
(2015) 'Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo'
Freeman, FE,Allen, AB,Stevens, HY,Guldberg, RE,McNamara, LM (2015) 'Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo'. Stem Cell Research & Therapy, 6 [DOI] [ARAN Link] [Details]
(2015) 'Differential beta(3) and beta(1) Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats'
Voisin, M,Mcnamara, LM (2015) 'Differential beta(3) and beta(1) Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats'. Anatomical Record-Advances In Integrative Anatomy And Evolutionary Biology, 298 :1548-1559 [DOI] [ARAN Link] [Details]
(2015) 'Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement'
Gunning, PS,Saikrishnan, N,Yoganathan, AP,McNamara, LM (2015) 'Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement'. Journal Of The Royal Society Interface, 12 [DOI] [Details]
(2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'
Dolan, EB;Haugh, MG;Voisin, MC;Tallon, D;McNamara, LM (2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'. Plos One, 10 [DOI] [Details]
(2015) 'Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants'
Birmingham, E;Kreipke, TC;Dolan, EB;Coughlin, TR;Owens, P;McNamara, LM;Niebur, GL;McHugh, PE (2015) 'Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants'. Annals Of Biomedical Engineering, 43 :1036-1050 [DOI] [Details]
(2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'
MA Brennan, MG Haugh, FJ O'Brien, LM McNamara (2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'. Hormone and Metabolic Research, [DOI] [Details]
(2014) 'Cell morphology and focal adhesion location alters internal cell stress'
Mullen, CA,Vaughan, TJ,Voisin, MC,Brennan, MA,Layrolle, P,McNamara, LM (2014) 'Cell morphology and focal adhesion location alters internal cell stress'. Journal Of The Royal Society Interface, 11 [DOI] [Details]
(2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'
Brennan, MA,Haugh, MG,O'Brien, FJ,McNamara, LM (2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'. Hormone and Metabolic Research, 46 :537-545 [DOI] [Details]
(2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'
Dolan, EB,Vaughan, TJ,Niebur, GL,Casey, C,Tallon, D,McNamara, LM (2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 136 [DOI] [Details]
(2014) 'Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution'
Brennan, MA;Gleeson, JP;O'Brien, EJ;McNamara, LM (2014) 'Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution'. Journal Of The Mechanical Behavior Of Biomedical Materials, 29 :161-170 [DOI] [Details]
(2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'
Dolan, EB;Vaughan, TJ;Niebur, GL;Casey, C;Tallon, D;McNamara, LM (2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 136 [DOI] [Details]
(2014) 'Multidisciplinary research into bonemechanobiology during normal physiology and the bone disease osteoporosis'
McNamara, LM (2014) 'Multidisciplinary research into bonemechanobiology during normal physiology and the bone disease osteoporosis'. Osteoporosis International, 25 [Details]
(2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'
Gunning, PS,Saikrishnan, N,McNamara, LM,Yoganathan, AP (2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'. Annals Of Biomedical Engineering, 42 :1195-1206 [DOI] [Details]
(2014) 'Simulation of Self Expanding Transcatheter Aortic Valve in a Realistic Aortic Root: Implications of Deployment Geometry on Leaflet Deformation'
Gunning, PS,Vaughan, TJ,McNamara, LM (2014) 'Simulation of Self Expanding Transcatheter Aortic Valve in a Realistic Aortic Root: Implications of Deployment Geometry on Leaflet Deformation'. Annals Of Biomedical Engineering, 42 :1989-2001 [DOI] [Details]
(2014) 'Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution'
Brennan, MA,Gleeson, JP,O'Brien, EJ,McNamara, LM (2014) 'Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution'. Journal Of The Mechanical Behavior Of Biomedical Materials, 29 :161-170 [DOI] [Details]
(2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'
PS Gunning, N Saikrishnan, LM McNamara, AP Yoganathan (2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'. Annals Of Biomedical Engineering, 42 (6):1195-1206 [DOI] [Details]
(2014) 'Multidisciplinary research into bonemechanobiology during normal physiology and the bone disease osteoporosis'
McNamara, LM (2014) 'Multidisciplinary research into bonemechanobiology during normal physiology and the bone disease osteoporosis'. Osteoporosis International, 25 [Details]
(2014) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2014) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'. Biomechanics And Modeling In Mechanobiology, 13 :85-97 [DOI] [ARAN Link] [Details]
(2013) 'Computational Modelling of the Mechanics of Trabecular Bone and Marrow Using Fluid Structure Interaction Techniques'
Birmingham, E,Grogan, JA,Niebur, GL,McNamara, LM,McHugh, PE (2013) 'Computational Modelling of the Mechanics of Trabecular Bone and Marrow Using Fluid Structure Interaction Techniques'. Annals Of Biomedical Engineering, 41 :814-826 [DOI] [Details]
(2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'
Vaughan, TJ,Haugh, MG,McNamara, LM (2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'. Journal Of The Royal Society Interface, 10 [DOI] [Details]
(2013) '2. Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'
Vaughan TJ, Verbruggen SW, McNamara LM. (2013) '2. Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'. International Journal For Numerical Methods In Engineering, [DOI] [ARAN Link] [Details]
(2013) 'Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy'
Freeman FE, Haugh MG, McNamara LM. (2013) 'Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy'. Journal Of Tissue Engineering And Regenerative Medicine, [DOI] [ARAN Link] [Details]
(2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'
Mullen, CA,Haugh, MG,Schaffler, MB,Majeska, RJ,McNamara, LM (2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'. Journal Of The Mechanical Behavior Of Biomedical Materials, 28 :183-194 [DOI] [Details]
(2013) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'
Verbruggen SW, Vaughan TJ, McNamara LM (2013) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'. Biomech Model Mechanobiol, [DOI] [Details]
(2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'
Mullen, C.A., Haugh, M.G., Schaffler, M.B., Majeska, R.J., McNamara, L.M. (2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'. Journal Of Mechanical Behavior Of Biomedical Materials, [ARAN Link] [Details]
(2013) 'Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques'
Birmingham, E., Grogan, J.A., Niebur, G.L., McNamara, L.M., McHugh, P.E. (2013) 'Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques'. Annals Of Biomedical Engineering, 41 (4):814-826 [DOI] [Details]
(2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'
Vaughan, TJ;Haugh, MG;McNamara, LM (2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'. Journal Of The Royal Society Interface, 10 [DOI] [Details]
(2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'
Mullen, CA;Haugh, MG;Schaffler, MB;Majeska, RJ;McNamara, LM (2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'. Journal Of The Mechanical Behavior Of Biomedical Materials, 28 :183-194 [DOI] [Details]
(2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'
Vaughan, TJ,Verbruggen, SW,McNamara, LM (2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'. International Journal For Numerical Methods In Biomedical Engineering, 29 :1361-1372 [DOI] [Details]
(2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'. Journal Of The Royal Society Interface, 9 :2735-2744 [DOI] [ARAN Link] [Details]
(2012) 'Temporal Changes in Bone Composition, Architecture, and Strength Following Estrogen Deficiency in Osteoporosis'
Brennan, O,Kuliwaba, JS,Lee, TC,Parkinson, IH,Fazzalari, NL,McNamara, LM,O'Brien, FJ (2012) 'Temporal Changes in Bone Composition, Architecture, and Strength Following Estrogen Deficiency in Osteoporosis'. Calcified Tissue International, 91 :440-449 [DOI] [Details]
(2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'
Vaughan, TJ,McCarthy, CT,McNamara, LM (2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'. Journal Of The Mechanical Behavior Of Biomedical Materials, 12 :50-62 [DOI] [ARAN Link] [Details]
(2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'
Dolan, EB,Haugh, MG,Tallon, D,Casey, C,McNamara, LM (2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'. Journal Of The Royal Society Interface, 9 :3503-3513 [DOI] [Details]
(2012) 'Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro'
Brennan O, O'Brien FJ, McNamara LM. (2012) 'Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro'. Hormone and Metabolic Research, 44 (2) [Details]
(2012) 'OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS IS REGULATED BY OSTEOCYTE AND OSTEOBLAST CELLS IN A SIMPLIFIED BONE NICHE'
Birmingham, E,Niebur, GL,McHugh, PE,Shaw, G,Barry, FP,McNamara, LM (2012) 'OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS IS REGULATED BY OSTEOCYTE AND OSTEOBLAST CELLS IN A SIMPLIFIED BONE NICHE'. European Cells & Materials, 23 :13-27 [ARAN Link] [Details]
(2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'
Vaughan, TJ;McCarthy, CT;McNamara, LM (2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'. Journal Of The Mechanical Behavior Of Biomedical Materials, 12 :50-62 [DOI] [Details]
(2012) 'OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS IS REGULATED BY OSTEOCYTE AND OSTEOBLAST CELLS IN A SIMPLIFIED BONE NICHE'
Birmingham, E;Niebur, GL;McHugh, PE;Shaw, G;Barry, FP;McNamara, LM (2012) 'OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS IS REGULATED BY OSTEOCYTE AND OSTEOBLAST CELLS IN A SIMPLIFIED BONE NICHE'. European Cells & Materials, 23 :13-27 [Details]
(2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'
Verbruggen, SW;Vaughan, TJ;McNamara, LM (2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'. Journal Of The Royal Society Interface, 9 :2735-2744 [DOI] [Details]
(2012) 'Temporal Changes in Bone Composition, Architecture, and Strength Following Estrogen Deficiency in Osteoporosis'
Brennan, O;Kuliwaba, JS;Lee, TC;Parkinson, IH;Fazzalari, NL;McNamara, LM;O'Brien, FJ (2012) 'Temporal Changes in Bone Composition, Architecture, and Strength Following Estrogen Deficiency in Osteoporosis'. Calcified Tissue International, 91 :440-449 [DOI] [Details]
(2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'
Dolan, EB;Haugh, MG;Tallon, D;Casey, C;McNamara, LM (2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'. Journal Of The Royal Society Interface, 9 :3503-3513 [DOI] [Details]
(2012) 'Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012)'
Brennan, O;O'Brien, FJ;McNamara, LM (2012) 'Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012)'. Hormone and Metabolic Research, 44 :154-154 [Details]
(2011) 'The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis'
Brennan, O,Kennedy, OD,Lee, TC,Rackard, SM,O'Brien, FJ,McNamara, LM (2011) 'The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis'. Journal Of Biomechanics, 44 :386-390 [DOI] [Details]
(2011) 'SITE SPECIFIC INCREASE IN HETEROGENEITY OF TRABECULAR BONE TISSUE MINERAL DURING OESTROGEN DEFICIENCY'
Brennan, MA,Gleeson, JP,Browne, M,O'Brien, FJ,Thurner, PJ,McNamara, LM (2011) 'SITE SPECIFIC INCREASE IN HETEROGENEITY OF TRABECULAR BONE TISSUE MINERAL DURING OESTROGEN DEFICIENCY'. European Cells & Materials, 21 [Details]
(2011) 'SITE SPECIFIC INCREASE IN HETEROGENEITY OF TRABECULAR BONE TISSUE MINERAL DURING OESTROGEN DEFICIENCY'
Brennan, MA;Gleeson, JP;Browne, M;O'Brien, FJ;Thurner, PJ;McNamara, LM (2011) 'SITE SPECIFIC INCREASE IN HETEROGENEITY OF TRABECULAR BONE TISSUE MINERAL DURING OESTROGEN DEFICIENCY'. European Cells & Materials, 21 [Details]
(2011) 'The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis'
Brennan, O;Kennedy, OD;Lee, TC;Rackard, SM;O'Brien, FJ;McNamara, LM (2011) 'The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis'. Journal Of Biomechanics, 44 :386-390 [DOI] [Details]
(2010) 'Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures'
McNamara, L.M. (2010) 'Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures'. Jourmal of the Royal Society Interface, 7 (44):353-372 [Details]
(2009) 'Attachment of osteocyte cell processes to the bone matrix'
McNamara, L.M., Majeska, R.J., Weinbaum, S., Friedrich, V., Schaffler, M.B. (2009) 'Attachment of osteocyte cell processes to the bone matrix'. Anatomical Record, [Details]
(2008) 'Strain amplification and integrin based signalling in osteocytes'
Wang, Y., McNamara, L.M., Schaffler, M.B., Weinbaum, S. (2008) 'Strain amplification and integrin based signalling in osteocytes'. Journal of Musculoskeletal and Neuronal Interactions, 8 (4):332-334 [Details]
(2008) 'Loss of trabeculae in osteoporotic cancellous bone by biomechanical means'
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2008) 'Loss of trabeculae in osteoporotic cancellous bone by biomechanical means'. Journal of the Royal Society Interface, 5 (5):1243-1253 [Details]
(2007) 'Model for the Role of Integrins in Flow Induced Mechanotransduction in Osteocytes'
Wang, Y., McNamara, L.M., Schaffler, M.B. Weinbaum, S.A. (2007) 'Model for the Role of Integrins in Flow Induced Mechanotransduction in Osteocytes'. Proceedings of the National Academy of Sciences, 10 (40):15941-15946 [Details]
(2007) 'The effect of patient-specific bone remodeling rates on remodelling/repair in trabecular bone'
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2007) 'The effect of patient-specific bone remodeling rates on remodelling/repair in trabecular bone'. III International congress on Computational Bioengineering, [Details]
(2007) 'Bone remodelling algorithms incorporating both strain and microdamage stimuli'
McNamara, L. M. & Prendergast, P. J. (2007) 'Bone remodelling algorithms incorporating both strain and microdamage stimuli'. Journal of Biomechanics, 40 (6):1381-1391 [Details]
(2006) 'Strength of cancellous bone trabecular tissue from normal, ovarectomized and drug-treated rats over the course of ageing'
McNamara, L.M., Lyons, C.G., Ederveen, A.H., Weinans, H., Price, C.J., Schaffler, M.B., Prendergast, P.J. (2006) 'Strength of cancellous bone trabecular tissue from normal, ovarectomized and drug-treated rats over the course of ageing'. BONE, 39 (2):392-400 [Details]
(2006) 'Stress-concentrating effect of resorption lacunae in trabecular bone'
McNamara, L.M., Van der Linden, J.C., Weinans, H., Prendergast, P.J. (2006) 'Stress-concentrating effect of resorption lacunae in trabecular bone'. Journal Of Biomechanics, 39 (4):734-741 [Details]
(2005) 'Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis'
McNamara, L.M., Prendergast, P.J. (2005) 'Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis'. European Journal of Morphology, 42 (01-Feb):99-109 [Details]
(2005) 'Bone tissue material properties are altered during Osteoporosis'
McNamara, L. M., Prendergast, P. J. and Schaffler, M. B. (2005) 'Bone tissue material properties are altered during Osteoporosis'. Journal of Musculoskeletal and Neuronal Interactions, 5 (4):342-343 [Details]

Book Chapters

  Year Publication
(2011) 'Bone as a Material'
McNamara, L.M. (2011) 'Bone as a Material' In: Comprehensive Biomaterials. :169-186 Amsterdam: Elsevier. [Details]
(2008) 'Bones of Contention'
McNamara, L.M. (2008) 'Bones of Contention' In: Perspectives in Design and Bioengeineering. [Details]
(2004) 'Bone for Life: Osteoporosis, Bone Remodelling and Computer Simulation'
Lee, T.C., McHugh, P.E., O'Brien, F.J., O'Mahoney, D., Taylor, D., Bruzzi, M., Rackard, S.M., Kennedy, O.D., Mahony, N.J., Harrison, N., Lohfield, S., Brennan, O., Gleeson, J., Hazenberg, J.G., Mullins, L., Tyndyk, M., McNamara, L.M., O'Kelly, K. (2004) 'Bone for Life: Osteoporosis, Bone Remodelling and Computer Simulation' In: Topics in Bio-Mechanical Engineering. :58-93 [Details]
(2004) 'Topics in Biomechanical Engineering'
Lee, T.C., McHugh, P.E., O’Brien, F.J., O’Mahoney, D., Taylor, D., Bruzzi, M., Rackard, S.M., Kennedy, O.D., Mahoney, N.J., Harrison, N., Lohfeld, S., Brennan, O., Hazenberg J.G., Mullins, L., Tyndyk, M., McNamara, L.M. O’ Kelly, K. and Prendergast, P.J. (2004) 'Topics in Biomechanical Engineering' In: Bone for life: osteoporosis, bone remodelling and computer simulation. Dublin & Galway: TCBE & NCBES. [Details]

Conference Publications

  Year Publication
(2012) Summer Bioengineering Conference
Verbruggen, Stefaan W and Vaughan, Ted J and McNamara, Laoise M (2012) Loading-induced interstitial fluid flow in bone mechanobiology: an FSI approach to the osteocyte environment Summer Bioengineering Conference , pp.517-518 [Details]
(2012) Summer Bioengineering Conference
Gunning, Paul S and Harewood, Frank J and Vaughan, Ted J and McNamara, Laoise M (2012) Transcatheter Aortic Valves: A Finite Element Study of Leaflet Stress Distribution in the In Vivo Environment Summer Bioengineering Conference , pp.1043-1044 [Details]
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Verbruggen, SW;Vaughan, TJ;McNamara, LM (2012) LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.517-518 [Details]
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Gunning, PS;Harewood, FJ;Vaughan, TJ;McNamara, LM (2012) TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.1043-1044 [Details]
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Haugh, MG;McNamara, LM (2012) THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.677-678 [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B
Coughlin, TR;Haugh, M;Voisin, M;Birmingham, E;McNamara, LM;Niebur, GL (2014) PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A
Vaughan, TJ;Haugh, MG;McNamara, LM (2014) FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B
Dolan, EB;Vaughan, TJ;Niebur, GL;Tallon, D;McNamara, LM (2014) UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A
Gunning, PS;Saikrishnan, N;Yoganathan, AP;McNamara, LM (2014) HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A [Details]
(2011) 2nd Proceedings of the Orthopaedic Research Society Annual Meeting, Long Beach, CA, USA
Birmingham, E., Niebur, G.L., McHugh, P.E. and McNamara, L.M. (2011) An investigation into the microenvironment of the stem cell niche 2nd Proceedings of the Orthopaedic Research Society Annual Meeting, Long Beach, CA, USA [Details]
(2012) Proceedings of Orthopaedic Research Society Annual Meeting, San Francisco, CA, USA
Birmingham, E., Niebur, G.L., McHugh, P.E. and McNamara, L.M. (2012) The Synergistic Effect of Osteocytes and Osteoblasts on the Osteogenic Differentiation of MSCs Proceedings of Orthopaedic Research Society Annual Meeting, San Francisco, CA, USA [Details]
(2012) Proceedings of the Annual Symposium on Computational Methods in Orthopaedic Biomechanics (Pre-ORS), Berkeley, CA, USA
Birmingham, E., Niebur, G.L., McNamara, L.M. and McHugh, P.E. (2012) Computational Modelling of Trabecular Bone Marrow Proceedings of the Annual Symposium on Computational Methods in Orthopaedic Biomechanics (Pre-ORS), Berkeley, CA, USA [Details]
(2014) FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW
Vaughan, TJ,Haugh, MG,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW [Details]
(2014) PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE
Coughlin, TR,Haugh, M,Voisin, M,Birmingham, E,McNamara, LM,Niebur, GL, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE [Details]
(2014) UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION
Dolan, EB,Vaughan, TJ,Niebur, GL,Tallon, D,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION [Details]
(2014) HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY
Gunning, PS,Saikrishnan, N,Yoganathan, AP,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY [Details]
(2012) THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS
Haugh, MG,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS , pp.677-678 [Details]
(2012) TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT
Gunning, PS,Harewood, FJ,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT , pp.1043-1044 [Details]
(2012) LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT
Verbruggen, SW,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT , pp.517-518 [Details]

Conference Contributions

  Year Publication
(2011) 2nd Proceedings of the Orthopaedic Research Society Annual Meeting,
Birmingham, E., Niebur, G.L., McHugh, P.E. and McNamara, L.M (2011) An investigation into the microenvironment of the stem cell niche. [Oral Presentation], 2nd Proceedings of the Orthopaedic Research Society Annual Meeting, Long Beach, CA, USA , 13-JAN-11 - 16-JAN-11. [Details]

Abstract

  Year Publication
(2015) The Effect of Stretching on the Osteogenic Differentiation and Mechanical Properties of Human Adipose Stem Cells.
Virjula, S,Zhao, F,Leivo, J,Vanhatupa, S,Honkala, A,Viehrig, M,Kreutzer, J,McNamara, LM,Kallio, P,Miettinen, S (2015) The Effect of Stretching on the Osteogenic Differentiation and Mechanical Properties of Human Adipose Stem Cells. Abstract [Details]
(2015) An Experimental and Computational Investigation of 3D Matrix Mechanics in Directing Stem Cell Lineage.
Haugh, MG,Vaughan, TJ,McNamara, LM,O'Brien, FJ,Heilshorn, SC (2015) An Experimental and Computational Investigation of 3D Matrix Mechanics in Directing Stem Cell Lineage. Abstract [Details]
(2015) Osteoblast-Osteocyte Differentiation within a Three Dimensional Matrix is Determined by Matrix Stiffness and Intercellular Separation.
Mc Garrigle, MJ,Mullen, CA,Owens, P,Voisin, MC,McNamara, LM (2015) Osteoblast-Osteocyte Differentiation within a Three Dimensional Matrix is Determined by Matrix Stiffness and Intercellular Separation. Abstract [Details]
(2015) Investigation of the In Vivo Vascularisation And Mineralisation Potentials of Endochondrally Primed Cellular Aggregates in a Rat Subcutaneous Delivery Model.
Freeman, FE,Allen, AB,Owens, P,Stevens, HY,Guldberg, RE,McNamara, LM (2015) Investigation of the In Vivo Vascularisation And Mineralisation Potentials of Endochondrally Primed Cellular Aggregates in a Rat Subcutaneous Delivery Model. Abstract [Details]
(2015) Endochondrally Priming of Human MSCs In Vitro Enhances their Mineralisation Potential without the Addition of Osteogenic Growth Factors.
Freeman, FE,Owens, P,Stevens, HY,Guldberg, RE,McNamara, LM (2015) Endochondrally Priming of Human MSCs In Vitro Enhances their Mineralisation Potential without the Addition of Osteogenic Growth Factors. Abstract [Details]

Conference Paper

  Year Publication
(2015) “Mechanical Characterization and Material Anisotropy of Ovine Bronchi Tissue”, Proceedings of the 21st Annual Bioengineering in Ireland Conference, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Maynooth, Ireland, January.
O’Shea, M.B., O’Brien, B., McHugh, P.E., and McNamara, L.M. (2015) “Mechanical Characterization and Material Anisotropy of Ovine Bronchi Tissue”, Proceedings of the 21st Annual Bioengineering in Ireland Conference, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Maynooth, Ireland, January. Conference Paper [Details]
(2011) Computational Modelling of Trabecular Bone Marrow. International workshop on Computational Mechanics.
Birmingham, E., Niebur, G., McNamara, L., McHugh, P. (2011) Computational Modelling of Trabecular Bone Marrow. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2011) Bone Mineral and Matrix Composition s Altered Prior to Significant Architectural Changes in Osteoporosis. Trans 57th Orthopaedic Research Society.
Brennan, O., Kuliwaba, J.S., Mahony, N.J., Parkinson, I.H., Fazzalari, N.L., McNamara, L.M., O'Brien, F.J. (2011) Bone Mineral and Matrix Composition s Altered Prior to Significant Architectural Changes in Osteoporosis. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Estrogen deficiency increased heterogeneity of bone tissue is anatomically regional dependent . Trans 57th Orthopaedic Research Society.
Brennan, M, Browne, M, O'Brien, F, Thurner, P J, McNamara, LM (2011) Estrogen deficiency increased heterogeneity of bone tissue is anatomically regional dependent . Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Experimental and Computational Investigation into Osteocyte Differentiation. European Chapter of the Tissue Engineering and Regenerative Medicine International Society.
Mullen, C., McNamara, L.M. (2011) Experimental and Computational Investigation into Osteocyte Differentiation. European Chapter of the Tissue Engineering and Regenerative Medicine International Society. Granada, Spain: Conference Paper [Details]
(2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Trans 56th Orthopaedic Research Society.
Brennan, O., Kennedy, O.D., Lee T.C., Rackard, S.M., O'Brien, F.J., McNamara, L.M. (2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Trans 56th Orthopaedic Research Society. New Orleans, USA: Conference Paper [Details]
(2011) An investigation into the microenvironment of the stem cell niche. Trans 57th Orthopaedic Research Society.
Birmingham E., Niebur G., McHugh P., McNamara L. (2011) An investigation into the microenvironment of the stem cell niche. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Computational analysis of transcatheter bioprosthetic valve design. International workshop on Computational Mechanics.
Gunning, P., O'Keeffe L., McNamara, L.M. (2011) Computational analysis of transcatheter bioprosthetic valve design. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2011) Site Specific Increase in Heterogeneity of Bone Tissue Mineral during Estrogen Deficiency. Trans 57th Orthopaedic Research Society.
Brennan, M, Browne, M, O'Brien, F, J, Thurner, P, J, McNamara, L (2011) Site Specific Increase in Heterogeneity of Bone Tissue Mineral during Estrogen Deficiency. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Multi-Scale Computational Modelling of Physiological Loading on Bone Cells. International workshop on Computational Mechanics.
Verbruggen, S., McNamara, L.M. (2011) Multi-Scale Computational Modelling of Physiological Loading on Bone Cells. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2010) Understanding the biomechanical microenvironment of the stem cell niche in bone. Proceedings of the 17th Congress of the European Society of Biomechanics.
Birmingham E., McNamara L., Niebur G., McHugh P.E. (2010) Understanding the biomechanical microenvironment of the stem cell niche in bone. Proceedings of the 17th Congress of the European Society of Biomechanics. Edinburgh: Conference Paper [Details]
(2009) Estrogen deficiency alters mineral production by osteoblastic cells in vitro. Trans 55th Orthopaedic Research Society.
McNamara, L.M., Brennan, M., Brennan, O. (2009) Estrogen deficiency alters mineral production by osteoblastic cells in vitro. Trans 55th Orthopaedic Research Society. Las Vegas, Nevada, USA: Conference Paper [Details]
(2008) Site-specific differences in bone mineral content from normal and ovariectomized bone. Trans 54th Orthopaedic Research Society.
McNamara, L.M., O'Brien F.J., Gillespie, C. (2008) Site-specific differences in bone mineral content from normal and ovariectomized bone. Trans 54th Orthopaedic Research Society. San Francisco, California: Conference Paper [Details]
(2007) Atherogenic treatment impairs age-related cortical bone adaptation in female rabbits. Trans 53rd Orthopaedic Research Society.
Fritton, J.C., Chinitz, N., Berman, D., McNamara, L.M., Choi, B.G., Badimon, J.J., Schaffler, M.B. (2007) Atherogenic treatment impairs age-related cortical bone adaptation in female rabbits. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2007) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Trans 53rd Orthopaedic Research Society.
Wang, Y., Weinbaum, S., McNamara, L.M., Schaffler, M.B. (2007) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2007) 3D simulation of damage repair along a single trabecular strut. Trans 53rd Orthopaedic Research Society.
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2007) 3D simulation of damage repair along a single trabecular strut. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2006) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Biomedical Engineering Society Fall Meeting.
Wang, Y., McNamara, L.M., Schaffler, M.B., Weinbaum, S. (2006) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Biomedical Engineering Society Fall Meeting. Conference Paper [Details]
(2006) Attachment of osteocyte cell processes to bone matrix, New Investigator Research Award. Trans 52nd Orthopaedic Research Society.
McNamara, LM, Majeska, RJ, Weinbaum, S, Friedrich, V, Schaffler, MB (2006) Attachment of osteocyte cell processes to bone matrix, New Investigator Research Award. Trans 52nd Orthopaedic Research Society. Conference Paper [Details]
(2006) Changes in bone tissue material properties during osteoporosis and anti-resorptive drug treatment are coupled to changes in mineral content. Trans 52nd Orthopaedic Research Society.
McNamara, L.M., Lyons, C.G., Ederveen, A.H., Weinans, H., Price, C.J., Schaffler, M.B., Prendergast, P.J. (2006) Changes in bone tissue material properties during osteoporosis and anti-resorptive drug treatment are coupled to changes in mineral content. Trans 52nd Orthopaedic Research Society. Chicago: Conference Paper [Details]
(2006) 3D Simulation of Damage Repair along a Single Trabecular Strut. Proceedings of the 5th World Congress of Biomechanics.
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2006) 3D Simulation of Damage Repair along a Single Trabecular Strut. Proceedings of the 5th World Congress of Biomechanics. Conference Paper [Details]
(2006) Development of osteocytic phenotype in vitro depends on extracellular matrix composition. Trans 52nd Orthopaedic Research Society.
McNamara, L.M., Herman, B.C., Majeska, R.J., Schaffler, M.B. (2006) Development of osteocytic phenotype in vitro depends on extracellular matrix composition. Trans 52nd Orthopaedic Research Society. Chicago: Conference Paper [Details]
(2005) Trabecular perforation during osteoporosis may begin with a chance in bone tissue elastic behavior. Trans 51st Orthopaedic Research Society.
McNamara, L.M., Prendergast, L.M. (2005) Trabecular perforation during osteoporosis may begin with a chance in bone tissue elastic behavior. Trans 51st Orthopaedic Research Society. Washington: Conference Paper [Details]
(2005) Bone tissue material properties are altered during osteoporosis, American Society for Bone and Mineral Research Harold B. Frost Young Investigator Award. Proc 35th Sun Valley Skeletal Tissue Biology Workshop.
McNamara, L.M., Prendergast, P.J., Schaffler, M.B (2005) Bone tissue material properties are altered during osteoporosis, American Society for Bone and Mineral Research Harold B. Frost Young Investigator Award. Proc 35th Sun Valley Skeletal Tissue Biology Workshop. Sun Valley, Idaho, USA: Conference Paper [Details]
(2004) Strength of single rat trabeculae in normal, ovariectomized and drug treated bone during ageing. Trans 50th Orthopaedic Research Society.
McNamara, L.M., Prendergast, P.J., Lyons, C.G., Ederveen, A.G.H., Weinans, H. (2004) Strength of single rat trabeculae in normal, ovariectomized and drug treated bone during ageing. Trans 50th Orthopaedic Research Society. San Francisco, California: Conference Paper [Details]
(2004) Can BMU activity be predicted using a mechano-regulatory rule combining strain and microdamage. Proc 14th European Society of Biomechanics.
McNamara, L.M., Prendergast, P.J. (2004) Can BMU activity be predicted using a mechano-regulatory rule combining strain and microdamage. Proc 14th European Society of Biomechanics. Hertogenbosch: Conference Paper [Details]
(2002) Finite Element Analysis and Bone Remodeling. Proc 4th Bone Fluid Flow Meeting, STEGA.
Prendergast, PJ, McNamara, LM, Kelly, DJ, Lacroix, D (2002) Finite Element Analysis and Bone Remodeling. Proc 4th Bone Fluid Flow Meeting, STEGA. Conference Paper [Details]
(2002) Micro-tensile testing of individual bone trabeculae from Normal, Ageing and Ovarectomized Bones. Proc 4th World Congress of Biomechanics.
McNamara, L.M., Prendergast, P.J., O' Kelly, K., Lyons, G. (2002) Micro-tensile testing of individual bone trabeculae from Normal, Ageing and Ovarectomized Bones. Proc 4th World Congress of Biomechanics. Calgary, Canada: Conference Paper [Details]
(2002) High stresses occur in bone trabeculae under low loads! A study using micro-serial sectioning techniques and finite element analysis. Proc 13th European Society of Biomechanics, ACTA of Bioengineering and Biomechanics.
McNamara, L.M., Van der Linden, J.C., Weinans, H., Prendergast, P.J. (2002) High stresses occur in bone trabeculae under low loads! A study using micro-serial sectioning techniques and finite element analysis. Proc 13th European Society of Biomechanics, ACTA of Bioengineering and Biomechanics. Conference Paper [Details]

Correction

  Year Publication
(2012) Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012).
Brennan, O,O'Brien, FJ,McNamara, LM (2012) Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012). Correction [Details]

Meeting

  Year Publication
(2013) A COMPUTATIONAL MODEL FOR PREOPERATIVE EVALUATION OF ASYMMETRIC DEPLOYED TRANSCATHETER AORTIC VALVES.
Gunning, P,Saikrishnan, N,Yoganathan, A,McNamara, LM (2013) A COMPUTATIONAL MODEL FOR PREOPERATIVE EVALUATION OF ASYMMETRIC DEPLOYED TRANSCATHETER AORTIC VALVES. Meeting [Details]

Reviews

  Year Publication
(2020) Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration.
Naqvi, SM;McNamara, LM (2020) Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration. LAUSANNE: FRONTIERS MEDIA SA Reviews [DOI] [Details]
(2019) Integrins in Osteocyte Biology and Mechanotransduction.
Geoghegan, IP;Hoey, DA;McNamara, LM (2019) Integrins in Osteocyte Biology and Mechanotransduction. NEW YORK: SPRINGER Reviews [DOI] [Details]
(2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures.
McNamara, LM (2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures. LONDON: ROYAL SOC Reviews [DOI] [Details]
(2016) Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template.
Freeman, FE;Stevens, HY;Owens, P;Guldberg, RE;McNamara, LM (2016) Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template. NEW ROCHELLE: MARY ANN LIEBERT, INC Reviews [DOI] [Details]
(2017) Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration.
Freeman, FE;McNamara, LM (2017) Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration. NEW ROCHELLE: MARY ANN LIEBERT, INC Reviews [DOI] [Details]
(2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures.
McNamara, LM (2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures. Reviews [DOI] [Details]

Teaching Interests

Medical Implant and Device Design (ME421)
Biomechanics (ME416)
Introduction to Biomedical Engineering (ME218)

Internal Collaborators

  Name Description of Collaboration
Internal Collaborators
Professor Frank Barry, National Centre for Biomedical Engineering SciencesProfessor Peter McHugh, Mechanical and Biomedical EngineeringDr. Patrick McGarry, Mechanical and Biomedical Engineering

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
External Collaborators
Professor Glen Niebur, University of Notre Dame, USAProfressor Ajit Yoganathan, Georgia Tech University, USAProfessor Richard Oreffo, University of Southampton, United KingdomDr. Philipp Thurner, University of Southampton, United KingdomDr. Martin Browne, University of Southampton, United KingdomProfessor Fergal O'Brien, Royal College of Surgeons in Ireland