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Staff Profiles

Prof John Dalton

BSc, PhD.

Contact Details

Professor of Molecular Parasitology
Orbsen Building
National University of Ireland Gal
H91 DK59
T: 091 494437
E: JOHNPIUS.DALTON@nuigalway.ie
@MPLNUIG

Biography

Prof. Dalton carried out his BSc and PhD in Zoology/Parasitology at University College Dublin, Ireland. Over the last 35 years he has researched in the USA (Johns Hopkins School of Medicine and National Institutes for Allergies and Infectious Diseases), Australia (Queensland Institute for Medical Research and University of Technology, Sydney), Canada (McGill University) and Northern Ireland (Queen’s University). His goal to understand the fundamental biology of parasites and their relationship with their hosts, animal and human. With this knowledge he is designing strategies to diagnose parasitic infections and to develop new treatments against some of man’s greatest scourges.

Peer Reviewed Journals

	Year	Publication
	(2020)	'Fasciola hepatica Extracellular Vesicles isolated from excretory-secretory products using a gravity flow method modulate dendritic cell phenotype and activity' Anna Murphy, Krystyna Cwiklinski, Richard Lalor, Barry O’Connell, Mark W Robinson, Jared Gerlach, Lokesh Joshi, Michelle Kilcoyne, John P Dalton, Sandra M O’Neill (2020) 'Fasciola hepatica Extracellular Vesicles isolated from excretory-secretory products using a gravity flow method modulate dendritic cell phenotype and activity'. Plos Neglected Tropical Diseases, [DOI] [Details]
	(2020)	'Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)' Jenna Shiels, Krystyna Cwiklinski, Raquel Alvarado, Karine Thivierge, Sophie Cotton, Bibiana Gonzales Santana, Joyce To, Sheila Donnelly, Clifford C Taggart, Sinead Weldon, John P Dalton (2020) 'Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)'. Plos Neglected Tropical Diseases, [DOI] [ARAN Link] [Details]
	(2020)	'Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases' Carolina De Marco Verissimo, Heather L Jewhurst, Irina G Tikhonova, Rolf T Urbanus, Aaron G Maule, John P Dalton, Krystyna Cwiklinski (2020) 'Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases'. Plos Neglected Tropical Diseases, [DOI] [ARAN Link] [Details]
	(2019)	'A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response' Soloviova K;Fox EC;Dalton JP;Caffrey CR;Davies SJ; (2019) 'A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response'. Plos Neglected Tropical Diseases, 13 (1) [DOI] [Details]
	(2019)	'Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells' de la Torre-Escudero, E,Gerlach, JQ,Bennett, APS,Cwiklinski, K,Jewhurst, HL,Huson, KM,Joshi, L,Kilcoyne, M,O'Neill, S,Dalton, JP,Robinson, MW (2019) 'Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells'. Plos Neglected Tropical Diseases, 13 [DOI] [Details]
	(2019)	'Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection' Carlile SR;Shiels J;Kerrigan L;Delaney R;Megaw J;Gilmore BF;Weldon S;Dalton JP;Taggart CC; (2019) 'Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection'. Scientific Reports, 9 (1) [DOI] [Details]
	(2019)	'Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts' Xiao-Xuan Zhang, Krystyna Cwiklinski, Rui-Si Hu, Wen-Bin Zheng, Zhao-An Sheng, Fu-Kai Zhang, Hany M Elsheikha, John P Dalton, Xing-Quan Zhu (2019) 'Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts'. BMC Genomics, [DOI] [Details]
	(2019)	'The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola' Cwiklinski K;Donnelly S;Drysdale O;Jewhurst H;Smith D;De Marco Verissimo C;Pritsch IC;O'Neill S;Dalton JP;Robinson MW; (2019) 'The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola'. Advances In Parasitology, 104 [DOI] [Details]
	(2018)	'Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase' Moore DS;Brines C;Jewhurst H;Dalton JP;Tikhonova IG; (2018) 'Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase'. Plos Computational Biology, 14 (10) [DOI] [Details]