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DR EVA ERZSEBET SZEGEZDI

M.Sc., Ph.D.

 
researcher
 

Biography

Affiliation: Lecturer in Biochemistry, NUI, Galway, Head of the Blood Cancer Biobank in Ireland, Principal investigator of the Cancer Niche Laboratory.  
Career information Dr. Szegezdi received her PhD in medical science in 2000 studying cell death signalling at the University of Debrecen, Hungary. She then joined the Cell Stress and Apoptosis Research laboratory led by Prof. Afshin Samali at the National University of Ireland, Galway in 2001 to study stress-induced cell death in heart and pancreatic cells. In 2010 she established her own research group as a Science Foundation Ireland Starting Investigator (SIRG) and an Irish Cancer Society Research Fellow focusing on how the tissues surrounding cancer cells protect the tumour from chemotherapeutics. She took up a university lecturer position in the Discipline of Biochemistry, National University of Ireland, Galway in 2011 where she is now a lecturer, the director of the Masters degree programme on cancer research and head of the Cancer Niche Research Laboratory and a principal investigator in the recently established Blood Cancer Network Ireland funded by SFI and the Irish Cancer Society.
Research and Clinical Interests: Current projects in her laboratory focus on the molecular wiring of cancer cells to predict how tumour cells respond to chemotherapeutics. A particularly interest of the laboratory is to understand the communication between the leukemia cells and the bone marrow tissue where leukemia cells reside in and how the bone marrow tissue makes the leukemic cells resistant to therapeutic drugs.

Research Interests

Mechanism of signal transduction in order to understand the driving forces of disease progression and to identify targets for therapy.

Identified that the pro-inflammatory cytokines interleukin-1b and interferon g act in synergy to induce beta-cell death and thus contribute to type I diabetes. Induction of nitric oxide synthase is necessary and sufficient to cause pancreatic beta cell apoptosis. Current in vivo studies assess the potential of IFNg neutralization to revert the progression of type I diabetes and promote pancreas recovery.

The potential of adult MSCs to repair ischemic heart damage was studied. The contribution of the components of ischemic conditions (hypoxia, nutrient deprivation, oxygen deprivation, inhibition of glues metabolism) to loss of cardiac muscle contractility and cell death was determined. Found that MSCs well tolerate the conditions which are damaging to cardiomyocyte function and survival. MSCs are able to retain functionality during prolonged ischemia by surviving on glycolytic energy production. Active glycolysis on the other hand provides an essential survival factor in MSCs and inhibition of glycolysis triggers rapid MSC death.

Regulation of apoptotic pathways in cancer cells and to the engineering of death ligands (TNF family of cytokines) for selective death receptor activation or receptor neutralization.

First demonstration that high affinity, receptor-selective variants of the death ligand, TRAIL, generated by computational design are more efficient death receptors activators and inducers of tumour cell death than wild type TRAIL. Found that the apoptosis-inducing potency of TRAIL is limited by its promiscuity, i.e. its ability to bind to four receptors due to formation of inactive heteromeric receptor complexes and fast kinetics of receptor activation is a key element in induction of apoptosis. Identified point mutations in TRAIL that provide receptor selectivity and thus enhance anti-tumour efficacy.

Current studies aim to develop a so called ratiometric analysis of protein expression. The working hypothesis is that rather than the absolute amount of a given protein, its amount relative to other proteins playing a role in a given biological process (i.e. the expression ratio of proteins) determines the biological response of a cell to any given stimulus.

Research Projects

  Project Start Date End Date
JANSSEN-CILAG LTD. - Molecular, cellular and genomic impact study of low-dose decitabine combined with oxidation-inducing agents' treatment in AML cell lines, with emphasis on the possible abolishment of decitabine- promoted chemoresistance mechanis 01-FEB-16 31-MAR-23
An interdisciplinary Approach to the Development of Effective Therapeutics to Target the Leukemic Microenvironment 20-JAN-16 01-MAY-18
Eimear O' Reilly IRC EP Postgrad Scholarship - Eradicating leukemia-initiating cells by breaking their dormancy 04-JAN-16 31-JAN-20
Leukemia Research 20-OCT-15 20-JUL-16
Janssen BioBank 10-JUL-15 10-JUL-17
Irish Blood Cancer Network (IBCN) 01-JUN-15 31-MAY-20
Blood Cancer Network Ireland 01-JUN-15 31-MAY-20
Irish Blood Cancer Network (IBCN) 01-JUN-15 31-MAY-20
Systems level leukenia research for the advanced training of experts in leukaemia 18-SEP-14 18-JUN-15
DEVELOPMENT OF EX VIVO DIAGNOSTIC MULTIVARIATE INDEX ASSAY FOR PREDICETION OF TREATMENT EFFICACY IN ACUTE LEUKEMIAS EVA SZEGEZDI 01-JAN-13 30-AUG-16
DEVELOPMENT OF EX VIVO DIAGNOSTIC MULTIVARIATE INDEX ASSAY FOR PREDICETION OF TREATMENT EFFICACY IN ACUTE LEUKEMIAS EVA SZEGEZDI 01-JAN-13 30-AUG-16
OPTIMISATION OF PROTEIN PURIFICATION AND STRUCTURE ANALYSIS TECHNIQUES 09 SIRG B 1575 ISTTF 11 EVAN SZEGEZDI 01-JAN-12 31-DEC-13
DEVELOPMENT OF 3D TUMOUR-SPHERES FOR TRANSLATIONAL CANCER RESEARCH MILL FUND 2011 EVA SZEGEZDI 01-JAN-12 31-AUG-15
Development of antagonistic cytokine variants for treatment of type I diabetes 01-DEC-08 30-NOV-09
Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis 01-DEC-09 30-NOV-12
Novel ratiometric approach to identify decisive molecular interactions of the TRAIL apoptotic machinery 01-OCT-09 30-SEP-13

Peer Reviewed Journals

  Year Publication
(2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'
Chonghaile TN, Gupta S;John M;Szegezdi E;Logue SE;Samali A (2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'. Biochem. Biophys. Res. Commun, 466 (1):40-45 [DOI] [Details]
(2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'
Chonghaile TN;Gupta S;John M;Szegezdi E;Logue SE;Samali A; (2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'. Biochemical And Biophysical Research Communications, 466 (1) [DOI] [Details]
(2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'
Gupta S;Cuffe L;Szegezdi E;Logue SE;Neary C;Healy S;Samali A; (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'. International Journal Of Cell Biology, 2010 [DOI] [Details]
(2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL'
Reeve JL;Szegezdi E;Logue SE;Ní Chonghaile T;O'Brien T;Ritter T;Samali A; (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL'. Journal Of Cellular And Molecular Medicine, 11 (3) [DOI] [Details]
(2015) 'G2/M arrest sensitises erythroid leukemia cells to TRAIL-induced apoptosis'
Cruet-Hennequart, S, Paavilainen T, O'Dwyer, M, Toth R, Carty, MP, Samali, A, Szegezdi, E (2015) 'G2/M arrest sensitises erythroid leukemia cells to TRAIL-induced apoptosis'. Journal of Leukemia, [Details]
(2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'
Szegezdi E;Duffy A;O'Mahoney ME;Logue SE;Mylotte LA;O'brien T;Samali A; (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochemical And Biophysical Research Communications, 349 (4) [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi E;Logue SE;Gorman AM;Samali A; (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (9) [DOI] [Details]
(2016) 'The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells'
Nathwani, SM,Greene, LM,Butini, S,Campiani, G,Williams, DC,Samali, A,Szegezdi, E,Zisterer, DM (2016) 'The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells'. International Journal Of Oncology, 49 :74-88 [DOI] [Details]
(2016) 'Recreating Complex Pathophysiologies In Vitro with Extracellular Matrix Surrogates for Anticancer Therapeutics Screening In Vitro Cancer Models with ECM Surrogates'
Shologu, N., Szegezdi, E., Lowery, A., Kerin, M., Pandit, A. and Zeugolis, D.I. (2016) 'Recreating Complex Pathophysiologies In Vitro with Extracellular Matrix Surrogates for Anticancer Therapeutics Screening In Vitro Cancer Models with ECM Surrogates'. Drug Discovery Today, 21 (9):1521-1531 [Details]
(2016) 'The Janus Face of Death Receptor Signaling during Tumor immunoediting'
Reilly, EO;Tirincsi, A;Logue, SE;Szegezdi, E (2016) 'The Janus Face of Death Receptor Signaling during Tumor immunoediting'. Frontiers In Immunology, 7 [DOI] [Details]
(2016) 'Decoy receptors block TRAIL sensitivity at supra-cellular level: the role of stromal cells in controlling tumour TRAIL-sensitivity'
O'Leary L, van der Sloot A, Serrano L, Reis C, Cool R, Quax WJ, Deegan S, Murillo L, Thompson K, de Sampaio P, Ryan AE, Singh Dhami SP, Murphy G, Szegezdi E (2016) 'Decoy receptors block TRAIL sensitivity at supra-cellular level: the role of stromal cells in controlling tumour TRAIL-sensitivity'. Oncogene, 35 (10):1261-1270 [DOI] [Details]
(2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy'
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams et al. (2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy'. Autophagy, 12 (1):1-222 [DOI] [Details]
(2016) 'Guiding the Killer and Bringing in Accomplices: Bispecific Antibody Treatment for Malignant Melanoma'
Eva Szegezdi, Martin Levelrkus (2016) 'Guiding the Killer and Bringing in Accomplices: Bispecific Antibody Treatment for Malignant Melanoma'. Journal Of Investigative Dermatology, 136 (2):362-364 [DOI] [Details]
(2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'
Chonghaile, TN,Gupta, S,John, M,Szegezdi, E,Logue, SE,Samali, A (2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'. Biochemical And Biophysical Research Communications, 466 :40-45 [DOI] [Details]
(2011) 'An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro'
Foley SA, Szegezdi E, Mulloy B, Samali A, Tuohy MG (2011) 'An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro'. Journal Of Natural Products, 74 (9):1851-1861 [DOI] [Details]
(2003) 'Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells'
Szondy Z, Sarang Z, Molnar P, Nemeth T, Piacentini M, Mastroberardino PG, Falasca L, Aeschlimann D, Kovacs J, Kiss I, Szegezdi E, Lakos G, Rajnavolgyi E, Birckbichler PJ, Melino G, Fesus L (2003) 'Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 100 (13):7812-7817 [DOI] [Details]
(2003) 'Ligation of retinoic acid receptor alpha regulates negative selection of thymocytes by inhibiting both DNA binding of nur77 and synthesis of bim'
Eva Szegezdi, Ildiko Kiss, Agnes Simon, Bernadett Blasko, Uwe Reichert, Serge Michel, Matyas Sandor, Laszlo Fesus and Zsuzsa Szondy (2003) 'Ligation of retinoic acid receptor alpha regulates negative selection of thymocytes by inhibiting both DNA binding of nur77 and synthesis of bim'. Journal Of Immunology, 170 (7):3577-3584 [DOI] [Details]
(1999) 'Clearance of apoptotic thymocytes is decreased by inhibitors of eicosanoid synthesis'
Mic FA, Molnar P, Kresztes T, Szegezdi E, Fesus L. (1999) 'Clearance of apoptotic thymocytes is decreased by inhibitors of eicosanoid synthesis'. Cell Death And Differentiation, 6 (7):593-595 [Details]
(1999) 'Regulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)-mediated apoptosis in activation-induced T cell death involves calcineurin and protein kinase C, respectively'
Toth R, Szegezdi E, Molnar G, Lord JM, Fesus L, Szondy Z (1999) 'Regulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)-mediated apoptosis in activation-induced T cell death involves calcineurin and protein kinase C, respectively'. European Journal Of Immunology, 29 (2):383-393 [Details]
(2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675 [DOI] [ARAN Link] [Details]
(2015) 'Molecular targets for novel drug development in pancreatic cancer'
Eimear O’ Reilly, Corrado Santocanale, Eva Szegezdi (2015) 'Molecular targets for novel drug development in pancreatic cancer'. Annals on Cancer Research, 2 (3) [Details]
(2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'
Séverine Cruet-Hennequart; Tanja Paavilainen; Michael O’Dwyer; Réka Tóth; Michael P Carty; Afshin Samali; Eva Szegezdi (2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'. Journal of Leukemia, 4 [DOI] [Details]
(2014) 'Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy'
Paul O’Reilly, Csaba Ortutay, Grainne Gernon, Enda O’Connell, Cathal Seoighe, Susan Boyce, Luis Serrano, Eva Szegezdi (2014) 'Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy'. BMC Genomics, 15 [DOI] [Details]
(2014) 'The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia Initiating cells'
Denis V. Baev, Janusz Krawczyk, Michael O’Dwyer, Eva Szegezdi (2014) 'The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia Initiating cells'. Leukemia research, 3 :79-82 [Details]
(2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'
van Dijk, M,Halpin-McCormick, A,Sessler, T,Samali, A,Szegezdi, E (2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'. Cell Death & Disease, 4 [DOI] [ARAN Link] [Details]
(2013) 'Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines'
Leanza L, O' Reilly P, Doyle A, Venturini E, Zoratti M, Szegezdi E, Szabo I (2013) 'Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines'. Current pharmaceutical design, [Details]
(2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'
Sessler T, Healy S, Samali A, Szegezdi E (2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'. Pharmacology & therapeutics, [DOI] [Details]
(2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'
Szegezdi, E,van der Sloot, AM,Mahalingam, D,O'Leary, L,Cool, RH,Munoz, IG,Montoya, G,Quax, WJ,de Jong, S,Samali, A,Serrano, L (2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'. Molecular & Cellular Proteomics, 11 [DOI] [Details]
(2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'
Gupta S, Giricz Z, Natoni A, Donnelly N, Deegan S, Szegezdi E, Samali A (2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'. Febs Letters, 586 (22):4023-4030 [DOI] [Details]
(2011) 'Targeting Trail Towards the Clinic'
Mahalingam, Devalingam,N.A.M. Oldenhuis, Corina,Szegezdi, Eva,J. Giles, Francis,G.E. de Vries, Elisabeth,de Jong, Steven,T. Nawrocki, Steffan (2011) 'Targeting Trail Towards the Clinic'. Current Drug Targets, 12 (1414):2079-2090 [Details]
(2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'
van Dijk M, Murphy E, Morrell M , Knapper S , O'Dwyer M, Samali A, Eva Szegezdi E. (2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'. Cancers, 3 :1329-1350 [ARAN Link] [Details]
(2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'
Szegezdi, E,Reis, CR,van der Sloot, AM,Natoni, A,O'Reilly, A,Reeve, J,Cool, RH,O'Dwyer, M,Knapper, S,Serrano, L,Quax, WJ,Samali, A (2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'. Journal Of Cellular And Molecular Medicine, 15 :2216-2231 [DOI] [Details]
(2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'
Mahalingam, D,Natoni, A,Keane, M,Samali, A,Szegezdi, E (2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'. British Journal Of Cancer, 102 :754-764 [DOI] [Details]
(2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'
Reis, CR,van der Sloot, AM,Natoni, A,Szegezdi, E,Setroikromo, R,Meijer, M,Sjollema, K,Stricher, F,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'. Cell Death & Disease, 1 [DOI] [Details]
(2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'
Gupta, S., Cuffe, L., Szegezdi, E., Logue, S., Neary, C., Healy, S., et al. (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'. Int J Cell Biol, 170215 [ARAN Link] [Details]
(2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'
Vrielink, J,Heins, MS,Setroikromo, R,Szegezdi, E,Mullally, MM,Samali, A,Quax, WJ (2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'. Febs Journal, 277 :1653-1665 [DOI] [Details]
(2009) 'Bcl-2 family on guard at the ER'
Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A. (2009) 'Bcl-2 family on guard at the ER'. American Journal Of Physiology: Cell Physiology, [ARAN Link] [Details]
(2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'
Mahalingam, D,Keane, M,Pirianov, G,Mehmet, H,Samali, A,Szegezdi, E (2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'. British Journal Of Cancer, 100 :1415-1424 [DOI] [Details]
(2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'
Reis, CR,van der Sloot, AM,Szegezdi, E,Natoni, A,Tur, V,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'. Biochemistry, 48 :2180-2191 [DOI] [Details]
(2009) 'Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?'
Plantivaux, A.,Szegezdi, E.,Samali, A.,Egan, L. (2009) 'Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?'. Annals N.Y. Acad. Sci, 1171 :38-49 [Details]
(2009) 'The mitochondrial death pathway: a promising therapeutic target in diseases'
Gupta, S.,Kass, G. E. N.,Szegezdi, E.,Joseph, B. (2009) 'The mitochondrial death pathway: a promising therapeutic target in diseases'. Journal Of Cellular And Molecular Medicine, 13 (66):1004-1033 [Details]
(2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'
Mahalingam, D.,Szegezdi, E.,Keane, M.,de Jong, S.,Samali, A. (2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'. Cancer Treatment Reviews, 35 (33):280-288 [Details]
(2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'
Szegezdi, E.,Reed Herbert, K.,Kavanagh, E. T.,Samali, A.,Gorman, A. M. (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 (6A6A):2482-2496 [Details]
(2008) 'Cytokine-induced beta-cell apoptosis is NO dependent, mitochondria-mediated and inhibited by bcl-xl'
Holohan, C., Szegezdi, E., Ritter, T., O'Brien, T., Samali, A. (2008) 'Cytokine-induced beta-cell apoptosis is NO dependent, mitochondria-mediated and inhibited by bcl-xl'. J. Cell Mol Med, 12 (2):591-606 [DOI] [Details]
(2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'
Tur, V,van der Sloot, AM,Reis, CR,Szegezdi, E,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'. Journal Of Biological Chemistry, 283 :20560-20568 [DOI] [Details]
(2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'
Mylotte, LA,Duffy, AM,Murphy, M,O'Brien, T,Samali, A,Barry, F,Szegezdi, E (2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'. Stem Cells and Development, 26 :1325-1336 [DOI] [Details]
(2008) 'Structure based design of a DR4 selective TRAIL variant'
Tur V, van der Sloot AM, Reis CR, Szegezdi E, Cool RH, Serrano L Samali A and Quax W (2008) 'Structure based design of a DR4 selective TRAIL variant'. Journal Of Biological Chemistry, 283 :20560-20568 [Details]
(2008) 'Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development'
Kiss, I.,Ruhl, R.,Szegezdi, E.,Fritzsche, B.,Toth, B.,Pongracz, J.,Perlmann, T.,Fesus, L.,Szondy, Z. (2008) 'Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development'. European Journal of Immunology, 38 (11):147-155 [Details]
(2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'
Samali, A,O'Mahoney, M,Reeve, J,Logue, S,Szegezdi, E,McMahon, J,Fearnhead, HO (2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'. Apoptosis, 12 :465-474 [DOI] [Details]
(2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'
Reeve, JLV,Szegezdi, E,Logue, SE,Chonghaile, TN,O'Brien, T,Ritter, T,Samali, A (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'. Journal Of Cellular And Molecular Medicine, 11 :509-520 [DOI] [Details]
(2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'
Ni Chonghaile, T,Concannon, CG,Szegezdi, E,Gorman, AM,Samali, A (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'. Apoptosis, 11 :1247-1255 [DOI] [Details]
(2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'
Szegezdi, E,Cahill, S,Meyer, M,O'Dwyer, M,Samali, A (2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'. British Journal Of Cancer, 94 :398-406 [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi, E.,Logue, S. E.,Gorman, A. M.,Samali, A. (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (99):880-885 [Details]
(2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'
Van der Sloot, AM,Tur, V,Szegezdi, E,Mullally, MM,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 103 :8634-8639 [DOI] [Details]
(2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'
Szegezdi, E,Duffy, A,O'Mahoney, ME,Logue, SE,Mylotte, LA,O'Brien, T,Samali, A (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochemical And Biophysical Research Communications, 349 :1406-1411 [DOI] [Details]
(2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochemical And Biophysical Research Communications, 327 :801-810 [Details]
(2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization'
Concannon, CG,FitzGerald, U,Holmberg, CI,Szegezdi, E,Sistonen, L,Samali, A (2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization'. Cell Stress & Chaperones, 10 :59-65 [Details]
(2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochem. Biophys. Res. Commun, 327 :801-810 [Details]
(2004) 'TGase2 is required for proper phagocytosis of apoptotic cells and to prevent autoimmunity'
Szondy, Z.,Sarang, Z.,Molnar, P.,Nemeth, T.,Piacentini, M.,Mastroberardino, P. G.,Falasca, L.,Aeschlimann, D.,Kovacs, J.,Kiss, I.,Szegezdi, E.,Lakos, G.,Rajnavolgyi, E.,Melino, G.,Fesus, L. (2004) 'TGase2 is required for proper phagocytosis of apoptotic cells and to prevent autoimmunity'. Tissue Antigens, 64 (44):342-343 [Details]
(2003) 'Caspase-12 and ER-stress-mediated apoptosis - The story so far'
Szegezdi, E.,Fitzgerald, U.,Samali, A. (2003) 'Caspase-12 and ER-stress-mediated apoptosis - The story so far'. Annals N.Y. Acad. Sci, 1010 :186-194 [Details]
(2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'
O'Mahoney, M. E.,Logue, S.,Szegezdi, E.,Stenson-Cox, C.,Fitzgerald, U.,Samali, A. (2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'. Annals N.Y. Acad. Sci, 1010 :728-732 [Details]
(2001) 'Cell death in HIV pathogenesis and its modulation by retinoids'
Szondy, Z.,Toth, R.,Szegezdi, E.,Reichert, U.,Ancian, P.,Fesus, L. (2001) 'Cell death in HIV pathogenesis and its modulation by retinoids'. Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways, 946 :95-107 [Details]
(2001) 'Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells'
Toth, R.,Szegezdi, E.,Reichert, U.,Bernardon, J. M.,Michel, S.,Ancian, P.,Kis-Toth, K.,Macsari, Z.,Fesus, L.,Szondy, Z. (2001) 'Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells'. European Journal of Immunology, 31 (55):1382-1391 [Details]
(2000) 'Apoptosis-linked in vivo regulation of the tissue transglutaminase gene promoter'
Szegezdi, E.,Szondy, Z.,Nagy, L.,Nemes, Z.,Friis, R. R.,Davies, P. J. A.,Fesus, L. (2000) 'Apoptosis-linked in vivo regulation of the tissue transglutaminase gene promoter'. Cell Death and Differentiation, 7 (1212):1225-1233 [Details]

Book Chapters

  Year Publication
(2011) 'Cytokine-induced b-cell stress and death in type 1 diabetes mellitus'
Vincenz, L; Szegezdi, E; Jäger, R; Holohan, C; O’Brien, T; Samali, A (2011) 'Cytokine-induced b-cell stress and death in type 1 diabetes mellitus' In: Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments. Croatia: Intech. [Details]

Conference Publications

  Year Publication
(2014) Irish Association for Cancer Research
O'Reilly, P; O'Connell, E; Gernon, G; Szegezdi, E. (2014) Panel of 25 co-acting genes identified as a powerful predictor of TRAIL sensitivity Irish Association for Cancer Research [Details]
(2011) Advances in Tnf Family Research
Quax, W. J.,Reis, C. R.,van der Sloot, A. M.,Tur, V.,Szegezdi, E.,Natoni, A.,Cool, R. H.,Samali, A.,Serrano, L. (2011) Designed Receptor Specific Rhtrail Variants Enhance Induction of Apoptosis in Cancer Cells Advances in Tnf Family Research , pp.726-727 [Details]
(2011) Advances in Tnf Family Research
Reis, C. R.,van der Sloot, A. M.,Szegezdi, E.,Natoni, A.,Tur, V.,Cool, R. H.,Samali, A.,Serrano, L.,Quax, W. J. (2011) Enhancement of Antitumor Properties of Rhtrail by Affinity Increase toward Its Death Receptors Advances in Tnf Family Research , pp.807-808 [Details]
(2011) Advances in Tnf Family Research
van der Sloot, A. M.,Szegezdi, E.,Reis, C. R.,Tur, V.,Quax, W. J.,Samali, A.,Serrano, L. (2011) Computational Design of Receptor Selective Trail Variants Advances in Tnf Family Research , pp.809-809 [Details]
(2011) Advances in Tnf Family Research
van Dijk, M.,Pronai, I.,Somali, A.,Szegezdi, E. (2011) Trail Resistance in Non-Transformed Cells Is Provided by Multiple Factors Advances in Tnf Family Research , pp.821-821 [Details]
(2010) American Society of Hematology Meeting Abstract
Morrell, R. C.,Szegezdi, E.,Halpin-McCormick, A.,Cawley, K.,Samali, A.,O'Dwyer, M. (2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia American Society of Hematology Meeting Abstract , pp.768-768 [Details]
(2009) AMER SOC CLINICAL ONCOLOGY Meeting Abstract
Mahalingam, D.,Medina, E.,Swords, R. T.,Kelly, K. R.,Carew, J. S.,Robbert, C. H.,Szegezdi, E.,Francis, G. J.,de Jong, S.,Nawrocki, S. T. (2009) Effect of sunitinib on TRAIL-induced apoptosis in preclinical colon cancer models AMER SOC CLINICAL ONCOLOGY Meeting Abstract [Details]
(2009) Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?
Plantivaux, A,Szegezdi, E,Samali, A,Egan, L (2009) NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance? , pp.38-49 [DOI] [Details]
(2008) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
Plantivaux A, Szegezdi E, Samali A, Egan LJ. (2008) TRAIL resistance in colon cancer cells: is NF-?B involved? APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS [Details]
(2007) Proceedings Of The American Association For Cancer Research. Annual Meeting
Szegezdi E, Mahalingam D, Van der Sloot A, Quax W, Keane M, Samali A (2007) Decoy-insensitive TRAIL variants kill tumour cells more efficiently without damaging non-transformed cells Proceedings Of The American Association For Cancer Research. Annual Meeting [Details]
(2003) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
SZEGEZDI, E et al. (2003) Caspase-12 and ER-stress-mediated apoptosis - The story so far APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS , pp.186-194 [Details]
(2003) American Society of Hematology. Meeting Abstract
Cahill, S.,Szegezdi, E.,Samali, A.,O'Dwyer, M. (2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis American Society of Hematology. Meeting Abstract [Details]
(2003) Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes
O'Mahoney, ME,Logue, S,Szegezdi, E,Stenson-Cox, C,Fitzgerald, U,Samali, A (2003) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes , pp.728-732 [DOI] [Details]

Conference Contributions

  Year Publication
(2003) Apoptosis: From Bench to the Bedside,
Logue SE, Szegezdi E, Samali, A (2003) A Characterisation of ER Stress-Induced Apoptosis. [Oral Presentation], Apoptosis: From Bench to the Bedside, Cork , 04-JUN-03 - 06-JUN-03. [Details]

Editorial

  Year Publication
(2016) Guiding the Killer and Bringing in Accomplices: Bispecific Antibody Treatment for Malignant Melanoma.
Szegezdi, E,Leverkus, M (2016) Guiding the Killer and Bringing in Accomplices: Bispecific Antibody Treatment for Malignant Melanoma. Editorial [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2016 President's award-Early stage researcher of the year, NUIG NUI, Galway
2016 Collaboration Achievement - winner Irish Laboratory Awards
2013 Irish Cancer Society: Researcher of the Year - finalist Irish Cancer Society
2009 Irish Cancer Society Research Fellowship - Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis. Irish Cancer Society
2009 Starting Investigator Research Grant Award Science Foundation Ireland

Professional Associations

  Association Function From / To
Irish Association for Cancer Research member 01-MAR-07 /
Haematology Association Ireland Member 01-JAN-13 / 05-APR-16
European Association for Cancer Research Member 01-JAN-13 / 05-APR-16
European Leukemia Net Member 01-JAN-13 / 05-APR-16
European Cell Death Organisation Member 01-JAN-13 / 01-JAN-17
Euroscientist Member 01-JAN-16 / 01-JAN-17
European Association for Cancer Research member 01-JUN-14 /
Biochemical Society member 01-JUL-05 /

Patents

  Patent Number Title Granted
US7994281 Improved Cytokine Design 09-AUG-11

Committees

  Committee Function From / To
Council of the Irish Association of Cancer Research (IACR) Council member 01-APR-16 /
Curriculum Review Commitee for Medical Programme Member 01-SEP-15 /
Management committee for the H2020 COST Action CM1106: Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells Member 01-JUN-15 / 30-NOV-16
Management commitee of Apoptosis Research Centre Member 01-DEC-14 /
French Cancer Institute Grant evaluation panel member 01-NOV-14 /
Learning, Teaching and Assessment Committee of SNS Member 01-JAN-13 / 01-JAN-15
Management committee of the Discipline of Biochemistry Member 01-SEP-11 /
Graduate Research Committee for structured PhD programme of Biochemistry Member 01-SEP-11 /

Employment

  Employer Position From / To
University of Debrecen, Hungary Postdoctoral researcher 01-DEC-00 / 30-SEP-01
National University of Ireland, Galway postdoctoral researcher 01-OCT-01 / 05-SEP-11
National University of Ireland, Galway Lecturer 06-SEP-11 / 28-FEB-17

Education

  Year Institution Qualification Subject
2000 University of Debrecen, Hungary PhD Medical Science
1996 University of Debrecen, Hungary Msc Biochemistry and Molecular Biology

Languages

  Language
English
Hungarian

Other Activities

  Description

Director of Blood Cancer Biobank Ireland (From June 2015 – present)

Editor for scientific, peer-reviewed journals (Dataset Papers in Biology)

Reviewer for a number of scientific journals: Cancer Research, Clinical Cancer Research, Journal of Dermatology, Leukemia Research, Journal of Cell Biology, Cell Death and Differentiation, Journal of Cellular and Molecular Medicine, Cancer Letters, Journal of Anatomy, FEBS Journal, FEBS Letters.

Scientific grant evaluator for: Horizon-2020; International Association for Cancer Research, French National Cancer Institute (INCa).

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2015 Tamas Sessler PhD Y
2015 Sanket More Msc Y
2015 Anna McCormick PhD Y
2015 Caitlin Simpson Msc Y
2014 Mairead Reidy PhD
2014 Gordon Greville Msc Y
2014 Owen Hoare Msc Y
2014 William McDaid Msc Y
2014 Paul O’Reilly PhD Y
2013 Paul Mac Eoin Msc Y
2012 Lynda O’Leary PhD Y
2011 Marianne van Dijk PhD N
2009 Devalingam Mahalingam PhD
2008 Eoin Murphy Msc Y
2008 Louise Mylotte PhD
2007 Triona NiChonghaile PhD
2006 Sara Cahill PhD N

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
Semester 2, 2011 - today Metabolism and Nutrition MD140
Semester 1, 2015-today Biomolecules, Metabolism and Energy MD138

Internal Collaborators

  Name Description of Collaboration
Internal Collaborators
Prof. Michael O’Dwyer (Professor of Haematology, UCHG), Prof. Paul Murphy (Head of Chemistry)Prof. Cathal Seoighe (Stokes Professor of Mathematics, Department of Mathematics),Dr. Dimitrios Zeugolis, Principal investigator, Network of Excellence for Functional Biomaterials) Prof. Afshin Samali (Head of ER Stress Research Group;  Discipline of Biochemistry), Prof. Corrado Santocanale (Chair in Molecular Medicine, NCBES, CCB)Dr. Adrienne Gorman (Head of Cell Death and Cell Survival group; Discipline of Biochemistry)

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
External Collaborators
Dr. Guillermo Montoya (Head of Macromolecular Crystallography Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain); Prof. Luis Serrano (Head of Systems Biology Unit, Centre for Genomic regulation (CRG), Barcelona, Spain);Dr. Steven Knapper, (professor of hematology, University of Cardiff, UK)Dr. Ildiko Szabo, (Department of Biology, University of Padova, Italy), Daniella Zisterer, (School of Biochemistry & Immunology, Trinity College Dublin)Almer van der Sloot (senior researcher, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Canada)Csaba Ortutay (CEO, Hiducator Ltd, bioinformatics online training, Tampere, Finland)